Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA045164-08A1
Application #
2091773
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Project Start
1987-09-01
Project End
2001-02-28
Budget Start
1996-05-01
Budget End
1997-02-28
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Dong, Yan; Ganther, Howard E; Stewart, Carleton et al. (2002) Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays. Cancer Res 62:708-14
Zhu, Zongjian; Jiang, Weiqin; Ganther, Howard E et al. (2002) Mechanisms of cell cycle arrest by methylseleninic acid. Cancer Res 62:156-64
Dong, Y; Lisk, D; Block, E et al. (2001) Characterization of the biological activity of gamma-glutamyl-Se-methylselenocysteine: a novel, naturally occurring anticancer agent from garlic. Cancer Res 61:2923-8
Ganther, H; Ip, C (2001) Thioredoxin reductase activity in rat liver is not affected by supranutritional levels of monomethylated selenium in vivo and is inhibited only by high levels of selenium in vitro. J Nutr 131:301-4
Jiang, W; Zhu, Z; Ganther, H E et al. (2001) Molecular mechanisms associated with Se-allylselenocysteine regulation of cell proliferation and apoptosis. Cancer Lett 162:167-73
Unni, E; Singh, U; Ganther, H E et al. (2001) Se-methylselenocysteine activates caspase-3 in mouse mammary epithelial tumor cells in vitro. Biofactors 14:169-77
Ganther, H E (2001) Selenium metabolism and mechanisms of cancer prevention. Adv Exp Med Biol 492:119-30
Medina, D; Thompson, H; Ganther, H et al. (2001) Se-methylselenocysteine: a new compound for chemoprevention of breast cancer. Nutr Cancer 40:12-7
Ganther, H E (2001) Selenotyrosine and related phenylalanine derivatives. Bioorg Med Chem 9:1459-66
Block, E; Birringer, M; Jiang, W et al. (2001) Allium chemistry: synthesis, natural occurrence, biological activity, and chemistry of Se-alk(en)ylselenocysteines and their gamma-glutamyl derivatives and oxidation products. J Agric Food Chem 49:458-70

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