) The Light Source and Confocal Microscopy Facility has two components with the unifying element of service to the investigators in the use of the various lasers and light sources. Services of the Light Source Facility (LSF) are maintenance, characterization and calibration of the light irradiation sources, operation of the lasers, record keeping, training, and consultation. With the use of laser scanning confocal microscopy in the program, the facility has been expanded to include the Confocal Microscopy Facility (CMF). The principal components of the LSF are: (1) The staff, consisting of the Director, Claudio H. Sibata, Ph.D., and the photophysics technician, Mr. John Mulvihill, M.S.; (2) Facilities, including lasers and other light sources, maintenance and repair equipment, work space and tools, and light source records; and (3) LSF equipment for measuring and calibrating light sources. To provide the same service for Project 3, Dr. Chris Lawson, Professor of Physics and Director of the UAB Laser Center, will service and characterize sources at UAB and will report on activities to Dr. Sibata. The principal components of the CMF are: (1) The staff, consisting of the co-Director, Anna-Liisa Nieminen, Ph.D., and the research assistant; and (2) Facilities, which consist of a laser-scanning confocal microscope and accessories. Dr. Sibata is Director of Core A with overall responsibility for the core and for services related to light sources for PDT. Dr. Nieminen is co-director with responsibility for the provision of expertise and training in the use of the confocal microscope under her control. Dr. Sibata will assist Dr. Nieminen in dosimetric assessments when one of the lasers is used to deliver a therapeutic dose in the microscope, or when it is necessary to ascertain the extent of potential damage to cells from the laser.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA048735-12
Application #
6588112
Study Section
Project Start
2002-05-01
Project End
2003-04-30
Budget Start
Budget End
Support Year
12
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Yang, Yang; Kennedy, Vance O; Updegraph 3rd, James B et al. (2012) Long directional interactions (LDIs) in oligomeric cofacial silicon phthalocyanines and other oligomeric and polymeric cofacial phthalocyanines. J Phys Chem A 116:8718-30
Yang, Yang; Samas, Brian; Kennedy, Vance O et al. (2011) Long, directional interactions in cofacial silicon phthalocyanine oligomers. J Phys Chem A 115:12474-85
Lee, Richard G; Vecchiotti, Mark A; Heaphy, John et al. (2010) Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse xenograft system. Laryngoscope 120:618-24
Chiu, Song-Mao; Xue, Liang-Yan; Lam, Minh et al. (2010) A requirement for bid for induction of apoptosis by photodynamic therapy with a lysosome- but not a mitochondrion-targeted photosensitizer. Photochem Photobiol 86:1161-73
Baron, Elma D; Malbasa, Christi L; Santo-Domingo, Diana et al. (2010) Silicon phthalocyanine (Pc 4) photodynamic therapy is a safe modality for cutaneous neoplasms: results of a phase 1 clinical trial. Lasers Surg Med 42:728-35
Rodriguez, Myriam E; Zhang, Ping; Azizuddin, Kashif et al. (2009) Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondria. Photochem Photobiol 85:1189-200
Ke, Malcolm S; Xue, Liang-yan; Feyes, Denise K et al. (2008) Apoptosis mechanisms related to the increased sensitivity of Jurkat T-cells vs A431 epidermoid cells to photodynamic therapy with the phthalocyanine Pc 4. Photochem Photobiol 84:407-14
Soldatova, Alexandra V; Kim, Junhwan; Rosa, Angela et al. (2008) Photophysical behavior of open-shell first-row transition-metal octabutoxynaphthalocyanines: CoNc(OBu)8 and CuNc(OBu)8 as case studies. Inorg Chem 47:4275-89
Kim, Junhwan; Rodriguez, Myriam E; Guo, Ming et al. (2008) Oxidative modification of cytochrome c by singlet oxygen. Free Radic Biol Med 44:1700-11
Wang, Ken Kang-Hsin; Wilson, Jeremy D; Kenney, Malcolm E et al. (2007) Irradiation-induced enhancement of Pc 4 fluorescence and changes in light scattering are potential dosimeters for Pc 4-PDT. Photochem Photobiol 83:1056-62

Showing the most recent 10 out of 102 publications