Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA050528-06S1
Application #
2093831
Study Section
Special Emphasis Panel (SRC (M1))
Project Start
1989-09-08
Project End
1997-01-31
Budget Start
1995-02-10
Budget End
1996-01-31
Support Year
6
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pharmacology
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Fu, X; McGrath, S; Pasillas, M et al. (1999) EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1. Oncogene 18:4920-9
Jacinto, E; Werlen, G; Karin, M (1998) Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity 8:31-41
Werlen, G; Jacinto, E; Xia, Y et al. (1998) Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J 17:3101-11
Licato, L L; Brenner, D A (1998) Analysis of signaling protein kinases in human colon or colorectal carcinomas. Dig Dis Sci 43:1454-64
Kamps, M P (1997) E2A-Pbx1 induces growth, blocks differentiation, and interacts with other homeodomain proteins regulating normal differentiation. Curr Top Microbiol Immunol 220:25-43
Knoepfler, P S; Kamps, M P (1997) The Pbx family of proteins is strongly upregulated by a post-transcriptional mechanism during retinoic acid-induced differentiation of P19 embryonal carcinoma cells. Mech Dev 63:5-14
Licato, L L; Keku, T O; Wurzelmann, J I et al. (1997) In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Gastroenterology 113:1589-98
Lu, Q; Kamps, M P (1997) Heterodimerization of Hox proteins with Pbx1 and oncoprotein E2a-Pbx1 generates unique DNA-binding specifities at nucleotides predicted to contact the N-terminal arm of the Hox homeodomain--demonstration of Hox-dependent targeting of E2a-Pbx1 in vivo. Oncogene 14:75-83
White, F C; Benehacene, A; Scheele, J S et al. (1997) VEGF mRNA is stabilized by ras and tyrosine kinase oncogenes, as well as by UV radiation--evidence for divergent stabilization pathways. Growth Factors 14:199-212
Knoepfler, P S; Kamps, M P (1997) The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of P Oncogene 14:2521-31

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