This program is aimed at better understanding how papovaviruses transform cells and induce tumors in animals. It focuses on major aspects of the transformation process from its earliest event, virus entry into a suitable target cell, to the full expression of a transformed phenotype. The fundamental theme of the work is that papovaviral transforming proteins function by perturbation of defined molecular events in intracellular signal transduction used in normal cell growth and differentiation.
The aim of the program is to understand the nature of these viral-cellular protein interactions in detail and to learn how they contribute to the various elements in a neoplastic phenotype. Experiments with polyoma, SV40, and human papilloma virus transforming proteins are planned. In each case, detailed analyses of the actions of known cellular protein targets of these proteins will be undertaken. Special emphasis will be placed on attempting to learn how each of these signalling proteins functions normally and after contacting the relevant viral transforming protein. Since papovaviral oncoproteins interact with important signalling molecules active in both the proximal and distal ends of key growth regulating pathways, information gained in the program is also likely to enhance one's understanding of normal signalling.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA050661-10
Application #
2667923
Study Section
Special Emphasis Panel (SRC (Q1))
Program Officer
Wong, May
Project Start
1989-07-01
Project End
1999-02-28
Budget Start
1998-03-06
Budget End
1999-02-28
Support Year
10
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
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