Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA051183-05S2
Application #
2094177
Study Section
Special Emphasis Panel (SRC (S1))
Project Start
1990-12-05
Project End
1997-02-28
Budget Start
1994-12-01
Budget End
1997-02-28
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Traicoff, June L; Periyasamy, Sumudra; Brattain, Michael G et al. (2003) Reconstitution of TGF-beta sensitivity in the VACO-411 human colon carcinoma line by somatic cell fusion with MCF-7. J Biomed Sci 10:253-9
Traicoff, J une L; Willson, James K V; Markowitz, Sanford D (2002) Early loss of deleted in colorectal carcinoma gene transcript detected in a group of benign colon adenomas. J Biomed Sci 9:716-20
Whitacre, C M; Zborowska, E; Willson, J K et al. (1999) Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness. Clin Cancer Res 5:665-72
Chatterjee, S; Berger, S J; Berger, N A (1999) Poly(ADP-ribose) polymerase: a guardian of the genome that facilitates DNA repair by protecting against DNA recombination. Mol Cell Biochem 193:23-30
Phillips Jr, W P; Gerson, S L (1999) Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer. Cancer Chemother Pharmacol 44:319-26
He, J; Whitacre, C M; Xue, L Y et al. (1998) Protease activation and cleavage of poly(ADP-ribose) polymerase: an integral part of apoptosis in response to photodynamic treatment. Cancer Res 58:940-6
Phillips Jr, W P; Willson, J K; Markowitz, S D et al. (1997) O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU. Cancer Res 57:4817-23
Whitacre, C M; Berger, N A (1997) Factors affecting topotecan-induced programmed cell death: adhesion protects cells from apoptosis and impairs cleavage of poly(ADP-ribose)polymerase. Cancer Res 57:2157-63
Chatterjee, S; Hirota, H; Belfi, C A et al. (1997) Hypersensitivity to DNA cross-linking agents associated with up-regulation of glucose-regulated stress protein GRP78. Cancer Res 57:5112-6
Whitacre, C M; Zborowska, E; Gordon, N H et al. (1997) Topotecan increases topoisomerase IIalpha levels and sensitivity to treatment with etoposide in schedule-dependent process. Cancer Res 57:1425-8

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