Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA052009-04S4
Application #
2094547
Study Section
Special Emphasis Panel (SRC (U1))
Project Start
1991-02-01
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Temple University
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Schultz, D C; Friedman, J R; Rauscher 3rd, F J (2001) Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev 15:428-43
Capili, A D; Schultz, D C; RauscherIII, F J et al. (2001) Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains. EMBO J 20:165-77
Fredericks, W J; Ayyanathan, K; Rauscher 3rd, F J (2001) Regulating the neoplastic phenotype using engineered transcriptional repressors. Cancer Lett 162 Suppl:S23-S32
Peng, H; Begg, G E; Schultz, D C et al. (2000) Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. J Mol Biol 295:1139-62
Fredericks, W J; Ayyanathan, K; Herlyn, M et al. (2000) An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene. Mol Cell Biol 20:5019-31
Ayyanathan, K; Fredericks, W J; Berking, C et al. (2000) Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. Cancer Res 60:5803-14
Li, X; Peng, H; Schultz, D C et al. (1999) Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. Cancer Res 59:5275-82
Reeves, F C; Burdge, G C; Fredericks, W J et al. (1999) Induction of antisense Pax-3 expression leads to the rapid morphological differentiation of neuronal cells and an altered response to the mitogenic growth factor bFGF. J Cell Sci 112 ( Pt 2):253-61
Ryan, R F; Schultz, D C; Ayyanathan, K et al. (1999) KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol Cell Biol 19:4366-78
Rauscher 3rd, F J; Morris, J F; Fredericks, W J et al. (1998) Characterization of monoclonal antibodies directed to the amino-terminus of the WT1, Wilms' tumor suppressor protein. Hybridoma 17:191-8

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