The primary objective of this project is to develop reliable, safe and cost-effective ultrasonic techniques for improved medical imaging and early tumor detection. The proposed work is based on concepts which have proven to be effective in prior applications in detection of ultrasonic signals, namely, frequency diversity and wavelet techniques. The primary objective is to improve detection of tumors, particularly at the early stages, which is both highly desirable and extremely challenging. Preliminary results from the application of these principles to medical images obtained from the breast and liver are highly encouraging and justify further research efforts. The various SSP algorithms significantly increased the contrast between the tumorous regions and the surrounding normal tissue, enabling easier identification of small cysts and lesions. In the proposed work, Constant-Q filtering and Wavelets will be used for signal decomposition and image enhancement. These are natural generalizations to SSP which provide added flexibility to employ non-Gaussian filter-banks designed for prescribed dual localization in time and frequency domains. The performance of all the algorithms will be evaluated with respect to conventional image processing methods.
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| Wheatley, Margaret A; Forsberg, Flemming; Dube, Neal et al. (2006) Surfactant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging. Ultrasound Med Biol 32:83-93 |
| Mogatadakala, Kishore V; Donohue, Kevin D; Piccoli, Catherine W et al. (2006) Detection of breast lesion regions in ultrasound images using wavelets and order statistics. Med Phys 33:840-9 |
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| Forsberg, Flemming; Lathia, Justin D; Merton, Daniel A et al. (2004) Effect of shell type on the in vivo backscatter from polymer-encapsulated microbubbles. Ultrasound Med Biol 30:1281-7 |
| El-Sherif, Dalia M; Lathia, Justin D; Le, Ngocyen T et al. (2004) Ultrasound degradation of novel polymer contrast agents. J Biomed Mater Res A 68:71-8 |
| Alacam, Burak; Yazici, Birsen; Bilgutay, Nihat et al. (2004) Breast tissue characterization using FARMA modeling of ultrasonic RF echo. Ultrasound Med Biol 30:1397-407 |
| Lathia, Justin D; Leodore, Lauren; Wheatley, Margaret A (2004) Polymeric contrast agent with targeting potential. Ultrasonics 42:763-8 |
| Oeffinger, Brian E; Wheatley, Margaret A (2004) Development and characterization of a nano-scale contrast agent. Ultrasonics 42:343-7 |
| Shankar, P Mohana; Dumane, Vishruta A; Piccoli, Catherine W et al. (2003) Computer-aided classification of breast masses in ultrasonic B-scans using a multiparameter approach. IEEE Trans Ultrason Ferroelectr Freq Control 50:1002-9 |
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