The specific aim of this exploratory investigation is to introduce a novel approach to enhance ultrasonic image resolution and, in parallel, examine the feasibility of tissue characterization by exploiting the scaling signature of ultrasound-matter interactions in general, and tissue in particular. One of the key objectives of the proposed work is to broaden the bandwidth of the signal obtained via conventional transducers. The work is motivated by a bandwidth broadening technique which was successfully implemented in a recent speech enhancement work in our laboratory. This approach is based on the extraction and modeling of the lower-law of 1/f/alpha noise component of the narrow-band signal which, in turn, allows us to synthesize higher frequency scales. This creates the effect of data collected over wider band of frequencies and is expected to enhance the resolution of ultrasonic medical images by recovering the frequencies of the original transmitted signal lost due to the attenuation mechanisms in the tissue. The modeling stage in the processing scheme exploits the geometric structure of the scale-to-scale variance progression of the wavelet coefficients. A natural dual use for this analysis step is to investigate the validity of this measure as a means for tissue characterization. Moreover, the resulting wide-band data can be used in conjunction with other signaling processing algorithms such as Split Spectrum Processing to further improve image quality for tumor detection.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA052823-10
Application #
6487752
Study Section
Project Start
2001-08-15
Project End
2003-05-31
Budget Start
Budget End
Support Year
10
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Drexel University
Department
Type
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Wheatley, Margaret A; Forsberg, Flemming; Oum, Kelleny et al. (2006) Comparison of in vitro and in vivo acoustic response of a novel 50:50 PLGA contrast agent. Ultrasonics 44:360-7
Wheatley, Margaret A; Forsberg, Flemming; Dube, Neal et al. (2006) Surfactant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging. Ultrasound Med Biol 32:83-93
Mogatadakala, Kishore V; Donohue, Kevin D; Piccoli, Catherine W et al. (2006) Detection of breast lesion regions in ultrasound images using wavelets and order statistics. Med Phys 33:840-9
Shankar, P M; Piccoli, C W; Reid, J M et al. (2005) Application of the compound probability density function for characterization of breast masses in ultrasound B scans. Phys Med Biol 50:2241-8
Forsberg, Flemming; Lathia, Justin D; Merton, Daniel A et al. (2004) Effect of shell type on the in vivo backscatter from polymer-encapsulated microbubbles. Ultrasound Med Biol 30:1281-7
El-Sherif, Dalia M; Lathia, Justin D; Le, Ngocyen T et al. (2004) Ultrasound degradation of novel polymer contrast agents. J Biomed Mater Res A 68:71-8
Alacam, Burak; Yazici, Birsen; Bilgutay, Nihat et al. (2004) Breast tissue characterization using FARMA modeling of ultrasonic RF echo. Ultrasound Med Biol 30:1397-407
Lathia, Justin D; Leodore, Lauren; Wheatley, Margaret A (2004) Polymeric contrast agent with targeting potential. Ultrasonics 42:763-8
Oeffinger, Brian E; Wheatley, Margaret A (2004) Development and characterization of a nano-scale contrast agent. Ultrasonics 42:343-7
Gefen, Smadar; Tretiak, Oleh J; Piccoli, Catherine W et al. (2003) ROC analysis of ultrasound tissue characterization classifiers for breast cancer diagnosis. IEEE Trans Med Imaging 22:170-7

Showing the most recent 10 out of 44 publications