The primary goals of this research are to design, construct and test a new class of wide-band, non-resonant, high efficiency ultrasound piezoelectric transducers based on modern materials. Based on the preliminary results, the design proposed is capable of operating in the frequency range 1 to 10 MHZ using one scan head only. The transducers will be designed for clinically useful frequencies and will be suited to interface with commercially available ultrasound machines. In contrast to conventional piezoelectric ceramic or composite transducer design in which the bandwidth is controlled by the thickness resonance frequency of the active element, this design will use non-resonant transducer structure. This will be achieved by using PVDF polymer as an active piezoelectric material. This material is well suited to fabricate novel ultrasound transducers with at least twice the bandwidth as that obtained with conventional (bandwidth limited) probes made of piezoelectric ceramics. In particular, the proposed design makes use of a multi-layer approach in which the bandwidth is determined by the thinnest active PVDF film and the sensitivity is proportional to the number of active polymer layers. In such an approach, the transducer will operate well below its resonance frequency and will be optimized to cover the relevant clinical imaging frequency bandwidth from 1 to 10 MHz. Such design will allow bandwidth enhancement and, at the same time, will provide overall sensitivity on a par with that available with conventional piezoelectric materials. This bandwidth enhancement provides improve signal-to-noise ration in image analyses, such as those based on the Split Spectrum Processing Approach, and tissue scatterer analysis with spectral redundancy. Furthermore, wide bandwidth transducers will allow improved ultrasound tissue characterization utilizing cepstrum based deconvolution. In addition, increased bandwidth will reduce speckle noise in the frequency compounding method of imaging. Another immediately useful aspect of wide bandwidth transducers is the allowance of frequency changes for conventional narrow band operation without changing the transducer. This ability is needed in intracavitary probes and is desirable for clinical convenience with all probes. The ultimate goal of the development of the wide-band pulse-echo polymer transducer is to interface it with modern ultrasound diagnostic machines and have an assembly capable of improve tissue characterization at clinically relevant frequencies using only one scanhead.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA052823-10
Application #
6487755
Study Section
Project Start
2001-08-15
Project End
2003-05-31
Budget Start
Budget End
Support Year
10
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Drexel University
Department
Type
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Wheatley, Margaret A; Forsberg, Flemming; Oum, Kelleny et al. (2006) Comparison of in vitro and in vivo acoustic response of a novel 50:50 PLGA contrast agent. Ultrasonics 44:360-7
Wheatley, Margaret A; Forsberg, Flemming; Dube, Neal et al. (2006) Surfactant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging. Ultrasound Med Biol 32:83-93
Mogatadakala, Kishore V; Donohue, Kevin D; Piccoli, Catherine W et al. (2006) Detection of breast lesion regions in ultrasound images using wavelets and order statistics. Med Phys 33:840-9
Shankar, P M; Piccoli, C W; Reid, J M et al. (2005) Application of the compound probability density function for characterization of breast masses in ultrasound B scans. Phys Med Biol 50:2241-8
Forsberg, Flemming; Lathia, Justin D; Merton, Daniel A et al. (2004) Effect of shell type on the in vivo backscatter from polymer-encapsulated microbubbles. Ultrasound Med Biol 30:1281-7
El-Sherif, Dalia M; Lathia, Justin D; Le, Ngocyen T et al. (2004) Ultrasound degradation of novel polymer contrast agents. J Biomed Mater Res A 68:71-8
Alacam, Burak; Yazici, Birsen; Bilgutay, Nihat et al. (2004) Breast tissue characterization using FARMA modeling of ultrasonic RF echo. Ultrasound Med Biol 30:1397-407
Lathia, Justin D; Leodore, Lauren; Wheatley, Margaret A (2004) Polymeric contrast agent with targeting potential. Ultrasonics 42:763-8
Oeffinger, Brian E; Wheatley, Margaret A (2004) Development and characterization of a nano-scale contrast agent. Ultrasonics 42:343-7
Shankar, P Mohana; Dumane, Vishruta A; Piccoli, Catherine W et al. (2003) Computer-aided classification of breast masses in ultrasonic B-scans using a multiparameter approach. IEEE Trans Ultrason Ferroelectr Freq Control 50:1002-9

Showing the most recent 10 out of 44 publications