We propose to use prospectively collected dietary data and frozen plasma and DNA specimens to address a series of hypotheses regarding major cancers and their premalignant precursors in men and women. The cancers and precursors that we will study are primarily those of the breast, colon and rectum, prostate, and lung. Project 1 will extend the biennial follow-up of 51,529 men who completed an extensive dietary questionnaire first in 1986 and again in 1990 and 1994 (The Health Professionals Follow-up Study, HPFS). Follow-up has been high and the study has already contributed substantially to information on diet and cancers of the prostate and colon. In the proposed continuation, we will extend and refine observations from our first eight years of follow-up and also address several new hypotheses using dietary, biochemical, and molecular data. Project 2 assesses diet in relation to newly diagnosed cases of adenomatous large bowel polyps in the HPFS and among 90,000 women in the Nurses Health Study I who completed dietary questionnaires in 1980,1984, 1986, 1990, and 1994. Important findings have already been published on dietary fiber, fat, red meat, folate, methionine, and alcohol. These findings and a series of new hypotheses will be evaluated with the extended follow-up, which will provide a total of 3,115 newly diagnosed adenomas. Project 3 evaluates histopathologic characteristics of benign breast disease biopsies between 1991 and 1997 among women enrolled in the Nurses Health Study II, and will analyze risk in relation to dietary data collected in 1991. Project 4 pools data from all major prospective studies of diet and cancer. Precise and unique information has already been obtained regarding the relation of dietary-fat intake to breast cancer. The extended follow- up will provide powerful data on diet and cancers of the breast and colon, and renal cell cancer and will allow a re-examination of potentially important new findings regarding dietary fat and breast cancer. Through these interrelated prospective studies, we anticipate a substantial increase in our understanding of, and thus the ability to prevent, the most important cancers of men and women.
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| Ma, Siyuan; Ogino, Shuji; Parsana, Princy et al. (2018) Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis. Genome Biol 19:142 |
| Tsang, Sabrina H; Peisch, Samuel F; Rowan, Brendan et al. (2018) Association between Trichomonas vaginalis and prostate cancer mortality. Int J Cancer : |
| He, Xiaosheng; Wu, Kana; Ogino, Shuji et al. (2018) Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas. Gastroenterology 155:355-373.e18 |
| Wu, Juan; Wilson, Kathryn M; Stampfer, Meir J et al. (2018) A 24-year prospective study of dietary ?-linolenic acid and lethal prostate cancer. Int J Cancer 142:2207-2214 |
| Hu, Yang; Ding, Ming; Yuan, Chen et al. (2018) Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. Gastroenterology 154:916-926.e9 |
| Tabung, Fred K; Wang, Weike; Fung, Teresa T et al. (2018) Association of dietary insulinemic potential and colorectal cancer risk in men and women. Am J Clin Nutr 108:363-370 |
| Grasso, Catherine S; Giannakis, Marios; Wells, Daniel K et al. (2018) Genetic Mechanisms of Immune Evasion in Colorectal Cancer. Cancer Discov 8:730-749 |
| Song, Mingyang; Wu, Kana; Meyerhardt, Jeffrey A et al. (2018) Fiber Intake and Survival After Colorectal Cancer Diagnosis. JAMA Oncol 4:71-79 |
| Ashar, Foram N; Mitchell, Rebecca N; Albert, Christine M et al. (2018) A comprehensive evaluation of the genetic architecture of sudden cardiac arrest. Eur Heart J 39:3961-3969 |
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