MicroRNAs for the diagnosis, prognosis and treatment of AMLs We have discovered alterations of microRNA genes in human leukemias, have discovered that a large fraction of microRNA genes are in chromosomal regions involved in genomic alterations in cancers, have discovered somatic and germ line mutations of microRNA genes in leukemias, and have developed a microRNA platform to investigate the global expression of microRNA genes in normal and leukemic tissues. In addition, we have discovered that miR15/miR16 cause apoptosis by targeting BCL2 and that miR221 and 222 targetKIT. In this proposal we apply our platform to investigate the role of microRNA genes in the pathogenesis and progression of AMLs and to develop better prognostic indicators of these diseases. In addition, the identification of altered microRNA genes involved in the pathogenesis of AMLs could provide new, important targets for the development of novel therapies based on microRNAs or their antisense, depending on whether the pathogenetic microRNAs function as suppressors or oncogenes respectively. We have already made significant progress and have identified microRNAs that may play an important role in AML. This project is highly integrated with the other projects of this program and provides them with microRNA targets involved in the apoptotic process.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA055164-18
Application #
8146114
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
18
Fiscal Year
2010
Total Cost
$301,442
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
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Zeng, Zhihong; Liu, Wenbin; Tsao, Twee et al. (2017) High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia. Haematologica 102:1537-1548
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