Abstract

The purpose of this Program Project is to bring together several qualified investigators to study growth-regulated gene expression during the G1 period. The area of investigation lies between the activation of early growth-regulated genes (of which c-myc and c-fos are the prototypes) and the onset of cellular DNA synthesis. Although different cell types and different mitogenic stimuli will be used, the basic question deals with the events occurring during the G1 period and their role in activating the genes of the DNA synthesizing machinery. These studies will involve investigators from different departments who have already been collaborating closely with each other.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA056309-03
Application #
3094607
Study Section
Special Emphasis Panel (SRC)
Project Start
1991-08-16
Project End
1995-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Corradini, Francesca; Bussolari, Rita; Cerioli, Davide et al. (2007) A degradation-resistant c-Myb mutant cooperates with Bcl-2 in enhancing proliferative potential and survival of hematopoietic cells. Blood Cells Mol Dis 39:292-6
Prisco, Marco; Maiorana, Arianna; Guerzoni, Clara et al. (2004) Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells. Mol Cell Biol 24:5421-33
Drakas, Robert; Tu, Xiao; Baserga, Renato (2004) Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 101:9272-6
Masciullo, Valeria; Susini, Tommaso; Zamparelli, Alessandra et al. (2003) Frequent loss of expression of the cyclin-dependent kinase inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas. Clin Cancer Res 9:5332-8
Claudio, Pier Paolo; Zamparelli, Alessandra; Garcia, Fernando U et al. (2002) Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. Clin Cancer Res 8:1808-15
Pagnini, Ugo; Florio, Salvatore; Crispino, Luca et al. (2002) Direct effect of a gonadotropin-releasing hormone agonist on the growth of canine mammary tumour cells. J Cell Biochem 85:470-81
Caputi, Mario; Groeger, Angela M; Esposito, Vincenzo et al. (2002) Loss of pRb2/p130 expression is associated with unfavorable clinical outcome in lung cancer. Clin Cancer Res 8:3850-6
Belletti, Barbara; Drakas, Robert; Morrione, Andrea et al. (2002) Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. Exp Cell Res 277:107-18
Pucci, Bruna; Claudio, Pier Paolo; Masciullo, Valeria et al. (2002) pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation. Oncogene 21:5897-905
Zini, N; Trimarchi, C; Claudio, P P et al. (2001) pRb2/p130 and p107 control cell growth by multiple strategies and in association with different compartments within the nucleus. J Cell Physiol 189:34-44

Showing the most recent 10 out of 67 publications