Abstract

The goals of this revised Program Project renewal application are the same as in the original application, i.e. a collaborative effort to elucidate the mechanism(s) of cell cycle progression in mammalian cells. The revised application brings together three investigators with an established expertise in cell cycle research, each in different areas: Bruno Calabretta in gene expression, Antonio Giordano in the role of cyclins and cyclin-associated proteins, and Renato Baserga in the field of growth factors and their receptors. These areas are tightly related to each other, since cyclins and cyclin-associated proteins are involved in regulation of gene expression, and both are dependent upon environmental signals, among which growth factors are prominent. The purpose of this proposed project is to utilize the expertise of three different investigators to establish firm connections between the activation of growth factors receptors, and modulations of cyclins and associated proteins and the expression of growth regulated genes, leading eventually to cell growth.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA056309-06
Application #
2769741
Study Section
Subcommittee G - Education (NCI)
Program Officer
Spalholz, Barbara A
Project Start
1991-08-16
Project End
2002-08-31
Budget Start
1998-09-15
Budget End
1999-08-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Corradini, Francesca; Bussolari, Rita; Cerioli, Davide et al. (2007) A degradation-resistant c-Myb mutant cooperates with Bcl-2 in enhancing proliferative potential and survival of hematopoietic cells. Blood Cells Mol Dis 39:292-6
Prisco, Marco; Maiorana, Arianna; Guerzoni, Clara et al. (2004) Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells. Mol Cell Biol 24:5421-33
Drakas, Robert; Tu, Xiao; Baserga, Renato (2004) Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 101:9272-6
Masciullo, Valeria; Susini, Tommaso; Zamparelli, Alessandra et al. (2003) Frequent loss of expression of the cyclin-dependent kinase inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas. Clin Cancer Res 9:5332-8
Claudio, Pier Paolo; Zamparelli, Alessandra; Garcia, Fernando U et al. (2002) Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. Clin Cancer Res 8:1808-15
Pagnini, Ugo; Florio, Salvatore; Crispino, Luca et al. (2002) Direct effect of a gonadotropin-releasing hormone agonist on the growth of canine mammary tumour cells. J Cell Biochem 85:470-81
Caputi, Mario; Groeger, Angela M; Esposito, Vincenzo et al. (2002) Loss of pRb2/p130 expression is associated with unfavorable clinical outcome in lung cancer. Clin Cancer Res 8:3850-6
Belletti, Barbara; Drakas, Robert; Morrione, Andrea et al. (2002) Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. Exp Cell Res 277:107-18
Pucci, Bruna; Claudio, Pier Paolo; Masciullo, Valeria et al. (2002) pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation. Oncogene 21:5897-905
Zini, N; Trimarchi, C; Claudio, P P et al. (2001) pRb2/p130 and p107 control cell growth by multiple strategies and in association with different compartments within the nucleus. J Cell Physiol 189:34-44

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