Abstract

The goals of this revised Program Project renewal application are the same as in the original application, i.e. a collaborative effort to elucidate the mechanism(s) of cell cycle progression in mammalian cells. The revised application brings together three investigators with an established expertise in cell cycle research, each in different areas: Bruno Calabretta in gene expression, Antonio Giordano in the role of cyclins and cyclin-associated proteins, and Renato Baserga in the field of growth factors and their receptors. These areas are tightly related to each other, since cyclins and cyclin-associated proteins are involved in regulation of gene expression, and both are dependent upon environmental signals, among which growth factors are prominent. The purpose of this proposed project is to utilize the expertise of three different investigators to establish firm connections between the activation of growth factors receptors, and modulations of cyclins and associated proteins and the expression of growth regulated genes, leading eventually to cell growth.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA056309-08
Application #
6171881
Study Section
Subcommittee G - Education (NCI)
Program Officer
Spalholz, Barbara A
Project Start
1991-08-16
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
8
Fiscal Year
2000
Total Cost
$710,203
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Corradini, Francesca; Bussolari, Rita; Cerioli, Davide et al. (2007) A degradation-resistant c-Myb mutant cooperates with Bcl-2 in enhancing proliferative potential and survival of hematopoietic cells. Blood Cells Mol Dis 39:292-6
Prisco, Marco; Maiorana, Arianna; Guerzoni, Clara et al. (2004) Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells. Mol Cell Biol 24:5421-33
Drakas, Robert; Tu, Xiao; Baserga, Renato (2004) Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 101:9272-6
Masciullo, Valeria; Susini, Tommaso; Zamparelli, Alessandra et al. (2003) Frequent loss of expression of the cyclin-dependent kinase inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas. Clin Cancer Res 9:5332-8
Claudio, Pier Paolo; Zamparelli, Alessandra; Garcia, Fernando U et al. (2002) Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. Clin Cancer Res 8:1808-15
Pagnini, Ugo; Florio, Salvatore; Crispino, Luca et al. (2002) Direct effect of a gonadotropin-releasing hormone agonist on the growth of canine mammary tumour cells. J Cell Biochem 85:470-81
Caputi, Mario; Groeger, Angela M; Esposito, Vincenzo et al. (2002) Loss of pRb2/p130 expression is associated with unfavorable clinical outcome in lung cancer. Clin Cancer Res 8:3850-6
Belletti, Barbara; Drakas, Robert; Morrione, Andrea et al. (2002) Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. Exp Cell Res 277:107-18
Pucci, Bruna; Claudio, Pier Paolo; Masciullo, Valeria et al. (2002) pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation. Oncogene 21:5897-905
Paggi, M G; Giordano, A (2001) Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother. Cancer Res 61:4651-4

Showing the most recent 10 out of 67 publications