Abstract

In Core C the previous Core B (Morphology and Morphometrics) and Core C (Automated Combined In Situ Hybridization and Immunohistochemistry Laboratory) have been combined and reorganized under the leadership of a proteomics expert to ensure that the techniques for molecular analysis and Iocalizarion by the three projects are adequately provided throughout the five years of this grant renewal and to direct the duties of the technician hired for this service. This core provides a facility for: 1. Automated in situ hydridization (ISH) and immunohistochemistry (IHC) 2. Confocal laser scanning microscopy, morphometrics 3. Transmission Electron Microscopy (TEM) and immunoelectron microscopy (IEM) 4. Proteomics (one- and two-dimensional SDS-PAGE, SELDI and mass spectrometry)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA056666-11
Application #
7418999
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
11
Fiscal Year
2007
Total Cost
$73,790
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Nagle, Raymond B; Algotar, Amit M; Cortez, Connie C et al. (2013) ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma. Prostate 73:1233-40
Sroka, Isis C; Sandoval, Cynthia P; Chopra, Harsharon et al. (2011) Macrophage-dependent cleavage of the laminin receptor ?6?1 in prostate cancer. Mol Cancer Res 9:1319-28
Sroka, Isis C; Anderson, Todd A; McDaniel, Kathy M et al. (2010) The laminin binding integrin alpha6beta1 in prostate cancer perineural invasion. J Cell Physiol 224:283-8
Sroka, Isis C; Pond, Gerald D; Nagle, Raymond B et al. (2009) Human Cell Surface Receptors as Molecular Imaging Candidates for Metastatic Prostate Cancer. Open Prost Cancer J 2:59-66
Ports, Michael O; Nagle, Ray B; Pond, Gerald D et al. (2009) Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis. Cancer Res 69:5007-14
King, Tamara E; Pawar, Sangita C; Majuta, Lisa et al. (2008) The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. PLoS One 3:e3535
Demetriou, Manolis C; Stylianou, Panayiota; Andreou, Maria et al. (2008) Spatially and temporally regulated alpha6 integrin cleavage during Xenopus laevis development. Biochem Biophys Res Commun 366:779-85
Sroka, Isis C; McDaniel, Kathy; Nagle, Raymond B et al. (2008) Differential localization of MT1-MMP in human prostate cancer tissue: role of IGF-1R in MT1-MMP expression. Prostate 68:463-76
Demetriou, Manolis C; Kwei, Kevin A; Powell, Marianne B et al. (2008) Integrin A6 Cleavage in Mouse Skin Tumors. Open Cancer J 2:1-4
Sroka, Isis C; Chen, Man Ling; Cress, Anne E (2008) Simplified purification procedure of laminin-332 and laminin-511 from human cell lines. Biochem Biophys Res Commun 375:410-3

Showing the most recent 10 out of 68 publications