The primary functions of the Clinical Core are in planning and implementing 3D conformal radiation therapy for patients chosen for the clinical studies of this Program Project. The Clinical Core is involved in the development of treatment protocols, is primarily responsible for obtaining patient specific information and for designing treatment plans, and it plays a key role in assuring the safe and accurate implementation of the multi-field treatments. In carrying out these tasks, the Clinical Core draws on and coordinates the resources of the other Cores. Specifically, the Clinical Core uses the programs developed by the Computer Core and the dosimetric data collected by the Dosimetry Core. In addition, with the progress of the Program Project, when new treatment planning tools become available from Research Project II, as well as new dosimetric and calculational techniques from Research Project III, the Clinical Core will test these programs and implement them. The Clinical Core will also provide support to the Research Projects. It provides support for conducting Research Project I (Clinical Investigations). For research on plan evaluation (Project II) and patient set-up uncertainty (Project III), the Clinical Core will coordinate the collection of clinical data, and participate in their evaluation. It will also support the computer-aid optimization project (Research Project II) by providing feedback and clinical evaluation. In as much as that we shall use equipment such as the multi-leaf collimators and the on-line imagers, which are new technologies, we plan to evaluate them and develop quality assurance protocols, and procedures for their use. The Clinical Core will also participate in the development of the methods and procedures to verify the accuracy of the dose delivery using on-line imager and in-vivo dosimetry.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA059017-05
Application #
5209274
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Bakst, Richard L; Lee, Nancy; Pfister, David G et al. (2011) Hypofractionated dose-painting intensity modulated radiation therapy with chemotherapy for nasopharyngeal carcinoma: a prospective trial. Int J Radiat Oncol Biol Phys 80:148-53
Santoro, Joseph; Kriminski, Sergey; Lovelock, D Michael et al. (2010) Evaluation of respiration-correlated digital tomosynthesis in lung. Med Phys 37:1237-45
Liu, Xiaoxiao; Saboo, Rohit R; Pizer, Stephen M et al. (2009) A SHAPE-NAVIGATED IMAGE DEFORMATION MODEL FOR 4D LUNG RESPIRATORY MOTION ESTIMATION. Proc IEEE Int Symp Biomed Imaging 2009:875-878
Santoro, Joseph P; Yorke, Ellen; Goodman, Karyn A et al. (2009) From phase-based to displacement-based gating: a software tool to facilitate respiration-gated radiation treatment. J Appl Clin Med Phys 10:2982
Sura, Sonal; Gupta, Vishal; Yorke, Ellen et al. (2008) Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience. Radiother Oncol 87:17-23
Greco, Carlo; Clifton Ling, C (2008) Broadening the scope of image-guided radiotherapy (IGRT). Acta Oncol 47:1193-200
Kriminski, Sergey A; Lovelock, D Michael; Seshan, Venkatraman E et al. (2008) Comparison of kilovoltage cone-beam computed tomography with megavoltage projection pairs for paraspinal radiosurgery patient alignment and position verification. Int J Radiat Oncol Biol Phys 71:1572-80
Lu, Renzhi; Radke, Richard J; Yang, Jie et al. (2008) Reduced-order constrained optimization in IMRT planning. Phys Med Biol 53:6749-66
Zhang, Qinghui; Pevsner, Alex; Hertanto, Agung et al. (2007) A patient-specific respiratory model of anatomical motion for radiation treatment planning. Med Phys 34:4772-81
Crouch, Jessica R; Pizer, Stephen M; Chaney, Edward L et al. (2007) Automated finite-element analysis for deformable registration of prostate images. IEEE Trans Med Imaging 26:1379-90

Showing the most recent 10 out of 121 publications