Core - Biostatistics

Nelson, David O.

Abstract

The role of the Statistics Core is to provide the essential program-wide expertise in experimental analysis and design, data acquisition, editing, and management, data analysis, and results interpretation. It will provide the capabilities for managing the project database, ensuring the integrity of the acquired data, estimating parameters of interest, assessing model appropriateness, integrating multiple endpoints into a consistent result, and comparing alternative approaches to analysis and results interpretation. An important aspect of the results interpretation process is evaluating the relationship of results from this program to results from studies of the atom-bomb survivors and other radiation exposed populations. These evaluations will contribute to determining the advisability of subsequent pursuit of health effects in the Chernobyl liquidator population, and assessing the overall utility of biological dosimeters in the study of low-dose human radiation biology.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Program Projects (P01)
• Project #: 2P01CA059431-05
• Application #: 5209293
• Support Year: 5
• Fiscal Year: 1996

Publications

Sigurdson, Alice J; Ha, Mina; Hauptmann, Michael et al. (2008) International study of factors affecting human chromosome translocations. Mutat Res 652:112-21

Noori, Peri; Hou, Saimei; Jones, Irene M et al. (2005) A comparison of somatic mutational spectra in healthy study populations from Russia, Sweden and USA. Carcinogenesis 26:1138-51

Jones, I M; Thomas, C B; Xi, T et al. (2005) The genetic basis for variation in radiation sensitivity in the general population. Radiat Res 163:700-1

Tucker, James D; Cofield, Jackie; Matsumoto, Kyomu et al. (2005) Persistence of chromosome aberrations following acute radiation: I, PAINT translocations, dicentrics, rings, fragments, and insertions. Environ Mol Mutagen 45:229-48

Tucker, James D; Cofield, Jackie; Matsumoto, Kyomu et al. (2005) Persistence of chromosome aberrations following acute radiation: II, does it matter how translocations are scored? Environ Mol Mutagen 45:249-57

Tucker, James D (2002) Sensitivity, specificity, and persistence of chromosome translocations for radiation biodosimetry. Mil Med 167:8-9

Gardner, Shea N; Tucker, James D (2002) The cellular lethality of radiation-induced chromosome translocations in human lymphocytes. Radiat Res 157:539-52

Thomas, Cynthia B; Nelson, David O; Pleshanov, Pavel et al. (2002) Induction and decline of HPRT mutants and deletions following a low dose radiation exposure at Chernobyl. Mutat Res 499:177-87

Jones, Irene M; Galick, Heather; Kato, Paula et al. (2002) Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the chernobyl nuclear reactor 6-13 years after exposure. Radiat Res 158:424-42

Jones, I M; Tucker, J D; Langlois, R G et al. (2001) Evaluation of three somatic genetic biomarkers as indicators of low dose radiation effects in clean-up workers of the Chernobyl nuclear reactor accident. Radiat Prot Dosimetry 97:61-7