This core component is designed to establish a common platform for information exchange among Program participants and provide common facilities for intensive computation. The information exchange platform will first consist of high capacity file and WEB server which will contain a signal and image data base shared by the Program participants. A simple internet-based teleconferencing/NetMeeting environment will also be set at each site for interactive discussions between PI's, research assistants and students. Last, it is proposed to set an """"""""intensive computation server"""""""" to be shared by all participants for calculations requiring large amount of memory (1 Gb ram) and/or long computations, such as 3D modeling, or processing of r.f. image sequences. Matlab as a programming language will allow sharing source code. Internet will be used as the standard method for communication. Five years of support are requested.

National Institute of Health (NIH)
National Cancer Institute (NCI)
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Thittai, Arun K; Yamal, Jose-Miguel; Ophir, Jonathan (2013) Small breast lesion classification performance using the normalized axial-shear strain area feature. Ultrasound Med Biol 39:543-8
Thittai, Arun K; Yamal, Jose-Miguel; Mobbs, Louise M et al. (2011) Axial-shear strain elastography for breast lesion classification: further results from in vivo data. Ultrasound Med Biol 37:189-97
Thittai, Arun K; Galaz, Belfor; Ophir, Jonathan (2011) Visualization of HIFU-induced lesion boundaries by axial-shear strain elastography: a feasibility study. Ultrasound Med Biol 37:426-33
Thittai, Arun K; Galaz, Belfor; Ophir, Jonathan (2010) Axial-shear strain distributions in an elliptical inclusion model: experimental validation and in vivo examples with implications to breast tumor classification. Ultrasound Med Biol 36:814-20
Patil, Abhay V; Krouskop, Thomas A; Ophir, Jonathan et al. (2008) On the differences between two-dimensional and three-dimensional simulations for assessing elastographic image quality: a simulation study. Ultrasound Med Biol 34:1129-38
Garra, Brian Stephen (2007) Imaging and estimation of tissue elasticity by ultrasound. Ultrasound Q 23:255-68
Doyley, Marvin M; Srinivasan, Seshadri; Dimidenko, Eugene et al. (2006) Enhancing the performance of model-based elastography by incorporating additional a priori information in the modulus image reconstruction process. Phys Med Biol 51:95-112
Hoyt, Kenneth; Forsberg, Flemming; Ophir, Jonathan (2006) Comparison of shift estimation strategies in spectral elastography. Ultrasonics 44:99-108
Hoyt, Kenneth; Forsberg, Flemming; Ophir, Jonathan (2006) Analysis of a hybrid spectral strain estimation technique in elastography. Phys Med Biol 51:197-209
Chandrasekhar, R; Ophir, J; Krouskop, T et al. (2006) Elastographic image quality vs. tissue motion in vivo. Ultrasound Med Biol 32:847-55

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