The Tissue Procurement Core Facility for t his Program Project will provide services to each investigator. This will enhance each project, increase the efficient use of time and funds, and ensure coordination between projects. The Core will obtain human tumor tissue and maintain a bank of frozen malignant tumors, adjacent non-malignant skin, non-sun exposed skin and peripheral blood lymphocytes. It will also maintain laboratory specimen coding to maintain patient confidentiality and prevent experimental bias. Tumor cell line will also be maintained in the Core and distributed amongst investigators as required. All specimens will be histologically verified. Central processing of tumors for mRNA, DNA, and protein will be provided for all projects through the Core facility allowing: 1) a safe, central repository of essential materials for the research project s with accurate coded record keeping capabilities. 2) efficient utilization of scarce materials by multiple investigators. 3) standardization of collection, storage, and processing procedures, ensuring uniformity of materials obtained by different investigators. 4) An efficient tracking, delivery, and processing system that adjusts and meets the tissue requirements for the program project.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA068233-06S1
Application #
6643610
Study Section
Project Start
2001-08-06
Project End
2003-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
6
Fiscal Year
2002
Total Cost
$196,218
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Wu, Wenting; 23andMe Research Team; Amos, Christopher I et al. (2018) Inverse Relationship between Vitiligo-Related Genes and Skin Cancer Risk. J Invest Dermatol 138:2072-2075
Yuan, Hua; Liu, Hongliang; Liu, Zhensheng et al. (2015) Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival. Int J Cancer 137:638-45
Wang, Li-E; Li, Chunying; Strom, Sara S et al. (2007) Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progression. Clin Cancer Res 13:6532-9
Wang, Li-E; Hsu, T C; Xiong, Ping et al. (2007) 4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: a case-control analysis. J Invest Dermatol 127:196-205
Brewster, Abenaa M; Lee, J Jack; Clayman, Gary L et al. (2007) Randomized trial of adjuvant 13-cis-retinoic acid and interferon alfa for patients with aggressive skin squamous cell carcinoma. J Clin Oncol 25:1974-8
Ewart-Toland, Amanda; Dai, Qi; Gao, Yu-Tang et al. (2005) Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis 26:1368-73
Wang, Li-E; Xiong, Ping; Strom, Sara S et al. (2005) In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis. J Natl Cancer Inst 97:1822-31
Moore, Brian A; Weber, Randal S; Prieto, Victor et al. (2005) Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. Laryngoscope 115:1561-7
Clayman, Gary L; Lee, J Jack; Holsinger, F Christopher et al. (2005) Mortality risk from squamous cell skin cancer. J Clin Oncol 23:759-65
Hail Jr, N; Lotan, R (2004) Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics. Apoptosis 9:437-47

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