Recent work has indicated that neural stem cells are present in adult mice and can be grown in long-term liquid culture. This has formed the impetus for a collaborative group of investigators with quite varying backgrounds to work together to fully characterize the normal murine embryo, post-natal and adult brain derived neural stem cells in both in vitro and in vivo systems as a base for developing approaches to evaluate mechanisms underlying the development of glioma and preclinical models for the biologic therapy of glioma. The Program project consists of 4 scientific projects, 2 laboratory cores and an administrative core. Project 1 focuses on neurotrophic stimulation of neuro progenitors while project 3 deals with transplantation of these neural stem cells to characterize in vivo behavior and address their ability to restore function. Project 4 focuses on the ability of Trka receptor transduction to alter the biologic behavior of C6 glioma cells. A support core for the separation of neurosphere derived cells by fluorescent activated cell sorting while another Core will be maintaining neurosphere cells in culture and glioma cell line cells for the use of all projects. In total these studies are designed to develop unique models which in turn should form a base for new clinical approaches to the therapy of glioma.
| Jang, Taichang; Savarese, Todd; Low, Hoi Pang et al. (2006) Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. Am J Pathol 168:1676-85 |
| Savarese, Todd M; Jang, Taichang; Low, Hoi Pang et al. (2005) Isolation of immortalized, INK4a/ARF-deficient cells from the subventricular zone after in utero N-ethyl-N-nitrosourea exposure. J Neurosurg 102:98-108 |
| Jang, Taichang; Litofsky, N Scott; Smith, Thomas W et al. (2004) Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Neurobiol Dis 15:544-52 |
| Lachyankar, Mahesh B; Condon, Peter J; Daou, Marie-Claire et al. (2003) Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells. J Neurosci Res 71:157-72 |
| Li, Li; Liu, Fenghua; Ross, Alonzo H (2003) PTEN regulation of neural development and CNS stem cells. J Cell Biochem 88:24-8 |
| Quesenberry, P J; Colvin, G A; Abedi, M et al. (2003) The marrow stem cell: the continuum. Bone Marrow Transplant 32 Suppl 1:S19-22 |
| Engstrom, Caron M; Demers, Delia; Dooner, Mark et al. (2002) A method for clonal analysis of epidermal growth factor-responsive neural progenitors. J Neurosci Methods 117:111-21 |
| Li, Li; Liu, Fenghua; Salmonsen, Rebecca A et al. (2002) PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Mol Cell Neurosci 20:21-9 |
| Schonhoff, Christopher M; Daou, Marie-Claire; Jones, Stephen N et al. (2002) Nitric oxide-mediated inhibition of Hdm2-p53 binding. Biochemistry 41:13570-4 |
| Recht, L D; Salmonsen, R; Rosetti, R et al. (2001) Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid. Biochem Pharmacol 62:755-63 |
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