The objective of the projects in this application is to improve the therapeutic results for children with ALL. Mechanisms and efficacy of leukemia cell killing (Project 2 & 3), as well as the development of new laboratory-based therapies (Project 1) all depend on ascertaining tumor specimens from all patients at diagnosis and relapse. As a result, the clinical projects require research resources which extend beyond direct patient care and clinical laboratory functions. Without clinical research support provided in this Core, it would be impossible to coordinate the proper collection of multiple research specimens (e.g., Day 7 marrow for apoptosis studies - Project 3; serial marrow specimens for minimal residual disease studies - Project 2, and timely follow-up of patients on long-term studies of cardiac and neuropsychologic toxicity (Project 4). Equally important for the success of this project is the biostatistical collaboration with individuals in this Core who provide abstraction, computerized entry, and quality control of data, as well as assist in the design and analysis of clinical research protocols. The purpose of this Core is to provide the following services that will be utilized by all of the research projects: 1) to collect research specimens and coordinate patient follow-up at DFCI; 2) to coordinate the collection of research specimens and follow-up data from consortium centers; 3) to ensure that study parameters are followed and confirm eligibility and patient registration; 4) to ensure accuracy of submitted data from outside sources; 5) to provide biostatistical collaboration for clinical research protocols (including all aspects of the design, conduct, analysis, and reporting of the clinical protocols, and the direction of data processing and data quality control assurance); 6) to provide data management for the collection of individual patient information; 7) to provide data coordinator to maintain a computerized database, with assured quality control and standardized reporting; 8) and to provide computing resources for data processing, forms design and statistical analyses.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Dana-Farber Cancer Institute
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Bansal, Neha; Barach, Paul; Amdani, Shahnawaz M et al. (2018) When is early septal myectomy in children with hypertrophic cardiomyopathy justified? Transl Pediatr 7:362-366
Mansour, Marc R; He, Shuning; Li, Zhaodong et al. (2018) JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med 215:1929-1945
Lipshultz, Steven E (2018) Letter by Lipshultz Regarding Article, ""Anthracycline Cardiotoxicity: Worrisome Enough to Have You Quaking?"" Circ Res 122:e62-e63
Temple, Jennifer L; Bernard, Christophe; Lipshultz, Steven E et al. (2017) The Safety of Ingested Caffeine: A Comprehensive Review. Front Psychiatry 8:80
Rahman, Sunniyat; Magnussen, Michael; León, Theresa E et al. (2017) Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. Blood 129:3221-3226
Hutchins, Kelley K; Siddeek, Hani; Franco, Vivian I et al. (2017) Prevention of cardiotoxicity among survivors of childhood cancer. Br J Clin Pharmacol 83:455-465
Bona, Kira; Blonquist, Traci M; Neuberg, Donna S et al. (2016) Impact of Socioeconomic Status on Timing of Relapse and Overall Survival for Children Treated on Dana-Farber Cancer Institute ALL Consortium Protocols (2000-2010). Pediatr Blood Cancer 63:1012-8
Seftel, Matthew D; Neuberg, Donna; Zhang, Mei-Jie et al. (2016) Pediatric-inspired therapy compared to allografting for Philadelphia chromosome-negative adult ALL in first complete remission. Am J Hematol 91:322-9
Fraser, Raphael André; Lipsitz, Stuart R; Sinha, Debajyoti et al. (2016) Approximate median regression for complex survey data with skewed response. Biometrics 72:1336-1347
Lipshultz, Steven E; Anderson, Lynn M; Miller, Tracie L et al. (2016) Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin-treated childhood acute lymphoblastic leukemia survivors. Cancer 122:946-53

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