Abstract

Core A will synthesize oligosaccharides derivatives, which are critical for the research projects I, II, and III. The Core is an important part of this program project in that it will provide invaluable oligosaccharides and glycopeptides to determine ligand specificity of carbohydrate-binding proteins and the roles of cell surface oligosaccharides in adhesion. In addition, the Core will provide carbohydrate rhicroarray including heparan sulfate oligosaccharide array for assaying carbohydrate-binding proteins.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA071932-15
Application #
8380248
Study Section
Special Emphasis Panel (ZCA1-RPRB-O)
Project Start
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
15
Fiscal Year
2012
Total Cost
$202,487
Indirect Cost
$67,771

  Institution

Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Nonaka, Motohiro; Fukuda, Michiko N; Gao, Chao et al. (2014) Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes. J Biol Chem 289:16478-86
Nonaka, Motohiro; Bao, Xingfeng; Matsumura, Fumiko et al. (2014) Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. Proc Natl Acad Sci U S A 111:8173-8
Sugihara, Kazuhiro; Shibata, Toshiaki K; Takata, Kayoko et al. (2013) Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans. FEBS Lett 587:3195-201
Lee, Seung Ho; Fukuda, Minoru (2013) Study of the biological functions of mucin type core 3 O-glycans. Methods Mol Biol 1022:41-50
Tsuboi, Koichiro; Hirakawa, Jotaro; Seki, Emiko et al. (2013) Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing. J Immunol 191:448-55
Suzuki-Anekoji, Misa; Suzuki, Atsushi; Wu, Sz-Wei et al. (2013) In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. J Biol Chem 288:5007-16
Okamoto, Teppei; Yoneyama, Mihoko Sutoh; Hatakeyama, Shingo et al. (2013) Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity. Mol Med Rep 7:359-64
Pols, Maaike S; van Meel, Eline; Oorschot, Viola et al. (2013) hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins. Nat Commun 4:1361
Ito, Yuki; Vela, Jose Luis; Matsumura, Fumiko et al. (2013) Helicobacter pylori cholesteryl ?-glucosides contribute to its pathogenicity and immune response by natural killer T cells. PLoS One 8:e78191
Hatakeyama, Shingo; Shibata, Toshiaki K; Tobisawa, Yuki et al. (2013) Tumor targeting by a carbohydrate ligand-mimicking peptide. Methods Mol Biol 1022:369-86

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