The objective of this core is to develop, breed and provide new transgenic mouse strains to be used for in vivo studies in the laboratory programs. The core will provide transgenic mice expression TIMP-1, ecotin and/or cystatins under constitutive and regulated promoters bred onto FVB/N and immunocompromised backgrounds, and humanized transgenic mice expressing human metalloproteinases under control of endogenous human promoters. The core will breed specific metalloprotease or inhibitor null-mutant mice onto backgrounds suitable for use in studies with isogenic and xenogenic cancer models. These models will lead to assessment of the pathogenesis and potential antiprotease therapy with greater specificity than animal models currently available.
| Sathler, Plinio Cunha; Lourenco, Andre Luiz; Miceli, Leonardo Alves et al. (2014) Structural model of haptoglobin and its complex with the anticoagulant ecotin variants: structure-activity relationship study and analysis of interactions. J Enzyme Inhib Med Chem 29:256-62 |
| LeBeau, Aaron M; Duriseti, Sai; Murphy, Stephanie T et al. (2013) Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Res 73:2070-81 |
| Darragh, Molly R; Schneider, Eric L; Lou, Jianlong et al. (2010) Tumor detection by imaging proteolytic activity. Cancer Res 70:1505-12 |
| Sounni, Nor E; Dehne, Kerstin; van Kempen, Leon et al. (2010) Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech 3:317-32 |
| Littlepage, Laurie E; Sternlicht, Mark D; Rougier, Nathalie et al. (2010) Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res 70:2224-34 |
| Kessenbrock, Kai; Plaks, Vicki; Werb, Zena (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52-67 |
| Lederle, Wiltrud; Hartenstein, Bettina; Meides, Alice et al. (2010) MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. Carcinogenesis 31:1175-84 |
| Barkan, David T; Hostetter, Daniel R; Mahrus, Sami et al. (2010) Prediction of protease substrates using sequence and structure features. Bioinformatics 26:1714-22 |
| Sun, Cheng; Su, Kai-Hung; Valentine, Jason et al. (2010) Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors. ACS Nano 4:978-84 |
| Andreu, Pauline; Johansson, Magnus; Affara, Nesrine I et al. (2010) FcRgamma activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell 17:121-34 |
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