This Core will provide personnel, supplies, and storage facilities for the procurement and management of biological materials for four of the Program Project components. Histological processing of fixed tissues and diagnostic assessment and micro-dissection by expert pathologists will also be provided. The biological materials to be managed for each Program Project component include: Pancreas Project: blood pancreatic juice, and animals and human pancreatic tissue; Ulcerative Colitis Project: colonic biopsy and resection tissue and blood; Colonic Screening Project: colonic biopsy and resection tissue, blood, and rectal swabs; and Patient Recruitment Core: colonic biopsy and resection tissue, blood, rectal swabs, and pancreatic resection tissue and matched blood. This ore resource will manage the disposition of tissues from procurement through histological processing and paraffin block and frozen tissue storage, to distribution to the individual research projects within and outside the Program Project. Distribution to outside investigators will be managed and approved by Dr. Bronner, in conjunction with the Program Executive Committee. All of Core work will be done in conjunction with the tissue acquisition and disposition data management system developed by the Biostatistics and Data Management Core.
| Passarelli, Michael N; Newcomb, Polly A; Makar, Karen W et al. (2015) Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization. Cancer Causes Control 26:467-73 |
| Adams, Scott V; Newcomb, Polly A; Burnett-Hartman, Andrea N et al. (2014) Rare circulating microRNAs as biomarkers of colorectal neoplasia. PLoS One 9:e108668 |
| Burnett-Hartman, Andrea N; Newcomb, Polly A; Hutter, Carolyn M et al. (2014) Variation in the association between colorectal cancer susceptibility loci and colorectal polyps by polyp type. Am J Epidemiol 180:223-32 |
| Burnett-Hartman, Andrea N; Newcomb, Polly A; Potter, John D et al. (2013) Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. Cancer Res 73:2863-72 |
| Burnett-Hartman, Andrea N; Passarelli, Michael N; Adams, Scott V et al. (2013) Differences in epidemiologic risk factors for colorectal adenomas and serrated polyps by lesion severity and anatomical site. Am J Epidemiol 177:625-37 |
| Burnett-Hartman, Andrea N; Newcomb, Polly A; Phipps, Amanda I et al. (2012) Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer. Am J Gastroenterol 107:1213-9 |
| Burnett-Hartman, Andrea N; Newcomb, Polly A; Mandelson, Margaret T et al. (2011) No evidence for human papillomavirus in the etiology of colorectal polyps. Cancer Epidemiol Biomarkers Prev 20:2288-97 |
| Adams, Scott V; Newcomb, Polly A; Burnett-Hartman, Andrea N et al. (2011) Circulating 25-hydroxyvitamin-D and risk of colorectal adenomas and hyperplastic polyps. Nutr Cancer 63:319-26 |
| Chia, Victoria M; Newcomb, Polly A; Lampe, Johanna W et al. (2007) Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 16:2697-703 |
| O'Sullivan, Jacintha; Risques, Rosa Ana; Mandelson, Margaret T et al. (2006) Telomere length in the colon declines with age: a relation to colorectal cancer? Cancer Epidemiol Biomarkers Prev 15:573-7 |
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