Abstract

The Tissue Analysis Core will provide the Program Project with histological and immunohistochemical analysis of cells grown in culture, explants grown as xenografts in athymic mice, and human tumor specimens which will be analysis for markers uncovered during laboratory investigations. We view the analysis of the signal transduction cascade in clinical human specimens as the ultimate test of the discoveries made in the cell culture and xenograft systems. The use of human specimens by members of the specific projects has already occurred and continues. Dr. Frierson will use his immunohistochemical expertise to interpret antibody staining in cell culture, experimental animal, and clinical human prostate cancer specimens.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA076465-01A2
Application #
6260121
Study Section
Subcommittee G - Education (NCI)
Project Start
1999-04-01
Project End
2004-01-31
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Axelrod, Mark J; Mendez, Rolando E; Khalil, Ashraf et al. (2015) Synergistic apoptosis in head and neck squamous cell carcinoma cells by co-inhibition of insulin-like growth factor-1 receptor signaling and compensatory signaling pathways. Head Neck 37:1722-32
DaSilva, John O; Amorino, George P; Casarez, Eli V et al. (2013) Neuroendocrine-derived peptides promote prostate cancer cell survival through activation of IGF-1R signaling. Prostate 73:801-12
Gioeli, Daniel; Wunderlich, Winfried; Sebolt-Leopold, Judith et al. (2011) Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer. Mol Cancer Ther 10:1581-90
Vomastek, Tomas; Iwanicki, Marcin P; Burack, W Richard et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol 28:6954-66
Casarez, Eli V; Dunlap-Brown, Marya E; Conaway, Mark R et al. (2007) Radiosensitization and modulation of p44/42 mitogen-activated protein kinase by 2-Methoxyestradiol in prostate cancer models. Cancer Res 67:8316-24
Deeble, Paul D; Cox, Michael E; Frierson Jr, Henry F et al. (2007) Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells. Cancer Res 67:3663-72
Gioeli, Daniel; Black, Ben E; Gordon, Vicki et al. (2006) Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization. Mol Endocrinol 20:503-15
Gioeli, Daniel (2005) Signal transduction in prostate cancer progression. Clin Sci (Lond) 108:293-308
Fu, Maofu; Rao, Mahadev; Wu, Kongming et al. (2004) The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. J Biol Chem 279:29436-49
Cooper, Carlton R; Sikes, Robert A; Nicholson, Brian E et al. (2004) Cancer cells homing to bone: the significance of chemotaxis and cell adhesion. Cancer Treat Res 118:291-309

Showing the most recent 10 out of 20 publications