Abstract

A program project is proposed by researchers at the Johns Hopkins Medical Institutions and the University of California at Berkeley entitled, """"""""High Throughput Genetic Analysis of Bladder Cancer and Urine Sediment."""""""" The goals of this proposal are to improve our understanding of the molecular genetic changes that drive bladder cancer progression as we develop and integrate novel high throughput approaches for the detection of these genetic alterations. These approaches will be used to translate our findings into the clinical setting where we will evaluate genetic alterations as predictors of disease outcome and targets for molecular detection. Unlike traditional methods of isolated investigators, this program emphasizes sharing of subjects, tissue samples, resources, technical expertise and data analysis strategies. Our program will not only offer clinical direction for basic research efforts, but will also facilitate the direct translation of state of the art high throughput technology into the basic laboratory and clinical arena.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA077664-08
Application #
7175299
Study Section
Subcommittee G - Education (NCI)
Program Officer
Kagan, Jacob
Project Start
1999-12-01
Project End
2009-11-30
Budget Start
2007-03-30
Budget End
2007-11-30
Support Year
8
Fiscal Year
2007
Total Cost
$926,468
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Duberow, David P; Brait, Mariana; Hoque, Mohammad O et al. (2016) High-performance detection of somatic D-loop mutation in urothelial cell carcinoma patients by polymorphism ratio sequencing. J Mol Med (Berl) 94:1015-24
Ferguson, Lynnette R; Chen, Helen; Collins, Andrew R et al. (2015) Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol 35 Suppl:S5-S24
Bishop, Justin A; Yonescu, Raluca; Batista, Denise et al. (2013) Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma. Hum Pathol 44:1982-8
Kinde, Isaac; Munari, Enrico; Faraj, Sheila F et al. (2013) TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine. Cancer Res 73:7162-7
Zhong, Xiaoli; Isharwal, Sumit; Naples, Jean M et al. (2013) Hypermethylation of genes detected in urine from Ghanaian adults with bladder pathology associated with Schistosoma haematobium infection. PLoS One 8:e59089
Chaux, Alcides; Cohen, Julie S; Schultz, Luciana et al. (2012) High epidermal growth factor receptor immunohistochemical expression in urothelial carcinoma of the bladder is not associated with EGFR mutations in exons 19 and 21: a study using formalin-fixed, paraffin-embedded archival tissues. Hum Pathol 43:1590-5
Dasgupta, Santanu; Shao, Chunbo; Keane, Thomas E et al. (2012) Detection of mitochondrial deoxyribonucleic acid alterations in urine from urothelial cell carcinoma patients. Int J Cancer 131:158-64
Chaux, Alcides; Karram, Sarah; Miller, Jeremy S et al. (2012) High-grade papillary urothelial carcinoma of the urinary tract: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. Hum Pathol 43:115-20
Begum, Shahnaz; Brait, Mariana; Dasgupta, Santanu et al. (2011) An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin Cancer Res 17:4494-503
Thaitrong, Numrin; Liu, Peng; Briese, Thomas et al. (2010) Integrated capillary electrophoresis microsystem for multiplex analysis of human respiratory viruses. Anal Chem 82:10102-9

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