Abstract

Over the past decade, knowledge about the pathogenesis of human tumors has been attributed to and limited by the availability of well characterized human tissues. With this in mind tissue facilities have emerged as a means of overseeing tissue distribution for investigative studies. To facilitate the availability of human tissues for the study of bladder cancer, the Tissue core will collect, store, process, and distribute tissues in a highly coordinated fashion. The Tissue Core will collect tissue in a manner that meets the needs of the individual investigators yet does not compromise patient care. The Tissue Core will store these tissues in such a way as to ensure long-term security and easy accessibility. The Tissue Core will process tissues so that they are suitable for further analysis. Finally, the Core will distribute tissues to investigators in a timely fashion. Through these activities, the Tissue Core will play a central role in the multidisciplinary approach to the study of bladder neoplasia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA077664-10
Application #
7754415
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-12-01
Budget End
2009-11-30
Support Year
10
Fiscal Year
2009
Total Cost
$81,409
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Duberow, David P; Brait, Mariana; Hoque, Mohammad O et al. (2016) High-performance detection of somatic D-loop mutation in urothelial cell carcinoma patients by polymorphism ratio sequencing. J Mol Med (Berl) 94:1015-24
Ferguson, Lynnette R; Chen, Helen; Collins, Andrew R et al. (2015) Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol 35 Suppl:S5-S24
Bishop, Justin A; Yonescu, Raluca; Batista, Denise et al. (2013) Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma. Hum Pathol 44:1982-8
Kinde, Isaac; Munari, Enrico; Faraj, Sheila F et al. (2013) TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine. Cancer Res 73:7162-7
Zhong, Xiaoli; Isharwal, Sumit; Naples, Jean M et al. (2013) Hypermethylation of genes detected in urine from Ghanaian adults with bladder pathology associated with Schistosoma haematobium infection. PLoS One 8:e59089
Chaux, Alcides; Cohen, Julie S; Schultz, Luciana et al. (2012) High epidermal growth factor receptor immunohistochemical expression in urothelial carcinoma of the bladder is not associated with EGFR mutations in exons 19 and 21: a study using formalin-fixed, paraffin-embedded archival tissues. Hum Pathol 43:1590-5
Dasgupta, Santanu; Shao, Chunbo; Keane, Thomas E et al. (2012) Detection of mitochondrial deoxyribonucleic acid alterations in urine from urothelial cell carcinoma patients. Int J Cancer 131:158-64
Chaux, Alcides; Karram, Sarah; Miller, Jeremy S et al. (2012) High-grade papillary urothelial carcinoma of the urinary tract: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. Hum Pathol 43:115-20
Begum, Shahnaz; Brait, Mariana; Dasgupta, Santanu et al. (2011) An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin Cancer Res 17:4494-503
Thaitrong, Numrin; Liu, Peng; Briese, Thomas et al. (2010) Integrated capillary electrophoresis microsystem for multiplex analysis of human respiratory viruses. Anal Chem 82:10102-9

Showing the most recent 10 out of 40 publications