Abstract

The Virus Vector Core will provide tissue-culture- and animal-derived viruses for all three projects. The core will make and titer stocks of recombinant MMTVs, G-MLVs and hybrid viruses. The core will also maintain and store all tissue culture lines and plasmid/viral DNAs used in all three projects. In conjunction with Core B (Mouse Breeding/Transgenic Core), the Virus Vector Core will also purify and provide mil-borne MMTV stocks for Projects 1 and 2. Dr. Paul Bates will supervise this core Dr. Bates will also make bi-monthly reports to the Executive Committee about new vector technologies that may be of use to the Program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA077760-02
Application #
6448499
Study Section
Subcommittee G - Education (NCI)
Project Start
2001-03-01
Project End
2002-02-28
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$103,677
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Mertz, Jennifer A; Kobayashi, Ryuji; Dudley, Jaquelin P (2007) ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer. J Virol 81:3503-13
Seo, Jin; Lozano, Mary M; Dudley, Jaquelin P (2005) Nuclear matrix binding regulates SATB1-mediated transcriptional repression. J Biol Chem 280:24600-9
Bhadra, Sanchita; Lozano, Mary M; Dudley, Jaquelin P (2005) Conversion of mouse mammary tumor virus to a lymphomagenic virus. J Virol 79:12592-6
Czarneski, Jennifer; Rassa, John C; Ross, Susan R (2003) Mouse mammary tumor virus and the immune system. Immunol Res 27:469-80
Broussard, Dana R; Mertz, Jennifer A; Lozano, M et al. (2002) Selection for c-myc integration sites in polyclonal T-cell lymphomas. J Virol 76:2087-99
Zhu, Quan; Dudley, Jaquelin P (2002) CDP binding to multiple sites in the mouse mammary tumor virus long terminal repeat suppresses basal and glucocorticoid-induced transcription. J Virol 76:2168-79
Czarneski, Jennifer; Berguer, Paula; Bekinschtein, Pedro et al. (2002) Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes. Eur J Immunol 32:945-56
Dudley, J P; Mertz, J A; Rajan, L et al. (2002) What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas. Leukemia 16:1086-98
Mertz, J A; Mustafa, F; Meyers, S et al. (2001) Type B leukemogenic virus has a T-cell-specific enhancer that binds AML-1. J Virol 75:2174-84