Abstract

The functions of this core will include biostatistical coordination and oversight of data collection and analysis. It will: 1) provide consultation regarding the designs, and analyses for the projects proposed in this grant, 2) collaborate with clinical investigators on the statistical and scientific aspects of planned protocols, including review and approval of protocols by the biostatistician before resubmission to the IRB and subsequent activation, 3) provide statistical support to the non-clinical investigators on an ongoing basis, 4) assist with preparation of analyses for publication and presentation, 5) provide quality controlled data management for the projects in this application, 6) collect and enter data generated by the clinical studies, 7) design forms for clinical studies, 8) develop and maintain the database for clinical protocols, 9) assist with quality control procedures, and 10) prepare interim data reports for ongoing clinical studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA078673-04
Application #
6666294
Study Section
Subcommittee G - Education (NCI)
Project Start
2002-09-30
Project End
2003-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
2002
Total Cost
$86,268
Indirect Cost

  Institution

Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Aldhamen, Y A; Seregin, S S; Kousa, Y A et al. (2013) Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2. Cancer Gene Ther 20:564-75
Morse, Michael A; Niedzwiecki, Donna; Marshall, John L et al. (2013) A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer. Ann Surg 258:879-86
Osada, Takuya; Morse, Michael A; Hobeika, Amy et al. (2012) Novel recombinant alphaviral and adenoviral vectors for cancer immunotherapy. Semin Oncol 39:305-10
Seregin, Sergey S; Aldhamen, Yasser A; Rastall, David P W et al. (2012) Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice. Vaccine 30:1492-501
Ren, Xiu-Rong; Wei, Junping; Lei, Gangjun et al. (2012) Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells. Breast Cancer Res 14:R89
Seregin, Sergey S; Amalfitano, Andrea (2011) Gene therapy for lysosomal storage diseases: progress, challenges and future prospects. Curr Pharm Des 17:2558-74
Hartman, Zachary C; Wei, Junping; Glass, Oliver K et al. (2011) Increasing vaccine potency through exosome antigen targeting. Vaccine 29:9361-7
Schuldt, Nathaniel J; Aldhamen, Yasser A; Appledorn, Daniel M et al. (2011) Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses. PLoS One 6:e24147
Seregin, Sergey S; Aldhamen, Yasser A; Appledorn, Daniel M et al. (2011) TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo. PLoS One 6:e22064
Osada, Takuya; Chen, Minyong; Yang, Xiao Yi et al. (2011) Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res 71:4172-82

Showing the most recent 10 out of 49 publications