CORE 1: PEPTIDE SYNTHESIS This core provides a central peptide synthesis resource for the program. The individual programs each depend on the use of synthetic peptides. Establishing in-house expertise for generating synthetic peptides is essential to the success of this program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA082713-02
Application #
6479432
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
2001-07-20
Project End
2002-06-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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Mitra, Sayantan; Duggineni, Srinivas; Koolpe, Mitchell et al. (2010) Structure-activity relationship analysis of peptides targeting the EphA2 receptor. Biochemistry 49:6687-95
Järvinen, Tero A H; Ruoslahti, Erkki (2010) Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice. Proc Natl Acad Sci U S A 107:21671-6
Richardson, Robyn D; Ma, Gil; Oyola, Yatsandra et al. (2008) Synthesis of novel beta-lactone inhibitors of fatty acid synthase. J Med Chem 51:5285-96
Jarvinen, Tero A H; Ruoslahti, Erkki (2007) Molecular changes in the vasculature of injured tissues. Am J Pathol 171:702-11
Zhang, Lianglin; Giraudo, Enrico; Hoffman, Jason A et al. (2006) Lymphatic zip codes in premalignant lesions and tumors. Cancer Res 66:5696-706
Browne, Cecille D; Hindmarsh, Elizabeth J; Smith, Jeffrey W (2006) Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor. FASEB J 20:2027-35
Koolpe, Mitchell; Burgess, Rosemary; Dail, Monique et al. (2005) EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. J Biol Chem 280:17301-11
Pai, Jih-Tung; Ruoslahti, Erkki (2005) Identification of endothelial genes up-regulated in vivo. Gene 347:21-33
Zhang, Lianglin; Hoffman, Jason A; Ruoslahti, Erkki (2005) Molecular profiling of heart endothelial cells. Circulation 112:1601-11

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