Core C Core C has both research and service goals, with the overall theme of developing new and useful imaging and dosimetry approaches to help optimize PDT, both for experimental protocols as well as clinical trials. The systems used by each project vary considerably, yet the file systems, data analysis, planning and dosimetry concepts can be centralized and inter-project communication in this area can significantly enhance the quality of research. The core is subdivided into four distinct aims, including (i) developing clinically viable tools for structural and functional imaging as well as dosimetry; (ii) providing baseline data for tumor models and imaging in vivo; (iii) methods for quantitative molecular imaging in vivo; and (iv) technology and methodology translation and adoption.
These aims all work with the projects to ensure that developments from one project may assist in another, and that methods, doses, image files, and developed software gets used to the highest potential. The core will assist Projects 1 and 2 in establishing truly useful dosimetry tools customized for the clinical trials. The variance of PS concentration will be studied in both skin and pancreatic cancer models. Quantification of key receptor changes in vivo will be developed. Specialized instrumentation and expertise exists across all four centers, with a large locus of tools and equipment in the MGH & Dartmouth sites, and this will be coordinated, scheduled and training provided through quarterly planned organizational meetings. Technical experts exist at each center though, and these frequent meetings coordinated by the core help to ensure that expertise and resources are utlized to maximum benfit. Travel between sites is planned judiciously to maximize cost/benefit, especially when training or prototyping measurements or trials, and internet conferences are utilized frequently. The complexity of technologies used is high, and sharing expertise about these significantly benefits the overall program participants. The complex issue of technology transfer is incorporated, as we have mulitiple partners in companies, as well as experienced technology transfer offices of each institution, and the CIMIT center at MGH. Coordination of this with high level planning meetings is central to ensuring that technologies and methodologies are translated into the program or out of the program into industry use.
TO PUBLIC HEALTH Core C provides the medical imaging, dosimetry, technology transfer expertise that is needed for the projects to be maximally successful. Since PDT is a technology-based intervention which requires imaging and analysis of therapeutic outcome, the core will help lead our efforts in excellence within this area. Superior treatment outcomes in the pancreas and skin cancer clinical trials will be a result
|Broekgaarden, Mans; Rizvi, Imran; Bulin, Anne-Laure et al. (2018) Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids. Oncotarget 9:13009-13022|
|Huang, Huang-Chiao; Rizvi, Imran; Liu, Joyce et al. (2018) Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery. Cancer Res 78:558-571|
|Huang, Huang-Chiao; Pigula, Michael; Fang, Yanyan et al. (2018) Immobilization of Photo-Immunoconjugates on Nanoparticles Leads to Enhanced Light-Activated Biological Effects. Small :e1800236|
|Wang, Hexuan; Mislati, Reem; Ahmed, Rifat et al. (2018) Elastography can map the local inverse relationship between shear modulus and drug delivery within the pancreatic ductal adenocarcinoma microenvironment. Clin Cancer Res :|
|Obaid, Girgis; Jin, Wendong; Bano, Shazia et al. (2018) Nanolipid Formulations of Benzoporphyrin Derivative: Exploring the Dependence of Nanoconstruct Photophysics and Photochemistry on Their Therapeutic Index in Ovarian Cancer Cells. Photochem Photobiol :|
|Marra, Kayla; LaRochelle, Ethan P; Chapman, M Shane et al. (2018) Comparison of Blue and White Lamp Light with Sunlight for Daylight-Mediated, 5-ALA Photodynamic Therapy, in vivo. Photochem Photobiol 94:1049-1057|
|Pereira, Stephen P; Jitlal, Mark; Duggan, Marian et al. (2018) PHOTOSTENT-02: porfimer sodium photodynamic therapy plus stenting versus stenting alone in patients with locally advanced or metastatic biliary tract cancer. ESMO Open 3:e000379|
|Maytin, Edward V; Kaw, Urvashi; Ilyas, Muneeb et al. (2018) Blue light versus red light for photodynamic therapy of basal cell carcinoma in patients with Gorlin syndrome: A bilaterally controlled comparison study. Photodiagnosis Photodyn Ther 22:7-13|
|Pereira, S P; Goodchild, G; Webster, G J M (2018) The endoscopist and malignant and non-malignant biliary obstruction. Biochim Biophys Acta Mol Basis Dis 1864:1478-1483|
|Bulin, Anne-Laure; Broekgaarden, Mans; Hasan, Tayyaba (2017) Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids. Sci Rep 7:16645|
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