The overall long-term objective of this Program Project is to identify novel dietary and hormonal determinants of breast colorectal and ovarian cancer risk in women, with the ultimate aim to find means for prevention and improved survival. The combination of questionnaire derived data with biomarkers, coupled with the long-follow-up, affords the opportunity to further understanding of the time course and mechanisms of cancer development. To achieve these objectives, we will relate a) prospectively collected data on diet, post-menopausal hormone use, smoking, and other behaviors; b) nutrient and hormone levels in prospectively collected blood; and c) genotyping information form archived DNA and tissue blocks; to incidence of breast colorectal, and ovarian cancer. This Program Project is based on the Nurses' Health Study cohort comprising 1212,700 women who were 30 to 55 years of age when enrolled in 1976. The Program Project serves as the central resource for the many related grants addressing incidence of cancer and other major chronic diseases that arise in this cohort of women. Project 1. Diet, exogenous hormones and breast cancer risk. Project 2. Diet, hormones and brisk of colorectal cancer. Project 3. Hormones, diet and risk of ovarian cancer. Project 4. Statistical innovations in risk modeling.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA087969-03
Application #
6475805
Study Section
Special Emphasis Panel (ZCA1-GRB-A (M1))
Program Officer
Hartmuller, Virginia W
Project Start
2000-09-12
Project End
2004-11-30
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
3
Fiscal Year
2002
Total Cost
$3,794,684
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Chiu, Yu-Han; Bertrand, Kimberly A; Zhang, Shumin et al. (2018) A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma. Int J Cancer 143:1914-1922
Petrick, Jessica L; Campbell, Peter T; Koshiol, Jill et al. (2018) Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project. Br J Cancer 118:1005-1012
He, Xiaosheng; Wu, Kana; Ogino, Shuji et al. (2018) Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas. Gastroenterology 155:355-373.e18
Wang, Sophia S; Carrington, Mary; Berndt, Sonja I et al. (2018) HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes. Cancer Res 78:4086-4096
Kim, Hanseul; Keum, NaNa; Giovannucci, Edward L et al. (2018) Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies. Int J Cancer 143:1047-1053
Liu, Li; Tabung, Fred K; Zhang, Xuehong et al. (2018) Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol 16:1622-1631.e3
Lin, Brian M; Li, Wen-Qing; Cho, Eunyoung et al. (2018) Statin use and risk of skin cancer. J Am Acad Dermatol 78:682-693
AlDubayan, Saud H; Giannakis, Marios; Moore, Nathanael D et al. (2018) Inherited DNA-Repair Defects in Colorectal Cancer. Am J Hum Genet 102:401-414
Li, Wen-Qing; Drucker, Aaron M; Cho, Eunyoung et al. (2018) Tetracycline use and risk of incident skin cancer: a prospective study. Br J Cancer 118:294-298
Bailey, Jessica N Cooke; Gharahkhani, Puya; Kang, Jae H et al. (2018) Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets. Invest Ophthalmol Vis Sci 59:629-636

Showing the most recent 10 out of 1708 publications