The goals of the PDT Physics core are to: 1) Provide Laser and other light source support for all projects; 2)Perform high-quality and reliable in vivo light dosimetry for projects (1,3,4 and 5); 3) Provide absolute lightdosimetry standards for all projects; 4) Provide explicit PDT dosimetry for tissue optical properties, drugconcentrations, and tissue oxygenation before, after, and during PDT.The physics core is responsible for calibrating the absolute output power of laser sources, ensuring that theyare traceable to standards maintained by the National Institute of Science and Technology (NIST). The coreperforms in vivo light dosimetry to achieve accurate light fluence measurement in PDT treatments, such asthe Intraperitoneal and Pleural PDT studies. Laser equipment operating at treatment wavelengths (532-730nm) for PDT are maintained, along with light sources covering wavelengths between 400 - 900 nm forabsorption and fluorescence spectroscopy. The physics core translates the spectroscopic techniquesdeveloped in the physics project for in vivo PDT dosimetry into clinical trials. The physics core ensures lasersafety, maintains quality assurance of physics equipment, and works to characterize light fluencedistributions in tissue. It helps to implement useful technologies developed in the physics project (Project 4)to routine clinical applications.
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