Core D: This Program Project (PPG) comprises a highly integrated effort between a number of programs, departments and schools within the University of Pennsylvania (PENN) and Roswell Park Cancer Institute (RPCI). The complimentary and interwoven nature of the aims for the projects and cores supports and encourages extensive sharing of data, tissues and core services. This synergistic design allows concurrent, bidirectional bedside-bench translation, where causal/mechanistic relationships can be established for new clinical trial observations and novel mechanisms can be evaluated for clinical relevance on an ongoing, rapidly updating basis. The main purpose of the Administrative Core is to provide an organizational framework that facilitates and oversees these collaborations, while avoiding dysfunctional micromanagement to keep the effort as a whole centered on the two major themes for this grant: 1) understanding the mechanisms and clinical contribution of pleural photodynamic therapy (pPDT) in patients undergoing radical pleurectomy (RP) and 2) obtaining improved mechanistic understanding of the impact of surgical resection on pPDT efficacy.
The specific aims for the Administrative Core are as follows:
Aim 1) Coordinate and supervise research efforts;
Aim 2) Enhance communication and collaboration;
Aim 3) Provide administrative and regulatory support.

Public Health Relevance

Core D This Program Project (PPG) comprises a highly integrated effort between a number of programs, departments and schools within the University of Pennsylvania (PENN) and Roswell Park Cancer Institute (RPCI). The complimentary and interwoven nature of the aims for the projects and cores supports and encourages extensive sharing of data, tissues and core services. The Administrative Core D will provide necessary coordination for the success of this program as a whole.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA087971-11A1
Application #
8741241
Study Section
Special Emphasis Panel (ZCA1-RPRB-B (M1))
Project Start
2000-07-01
Project End
2015-06-30
Budget Start
2014-09-10
Budget End
2015-06-30
Support Year
11
Fiscal Year
2014
Total Cost
$34,123
Indirect Cost
$12,796
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Ahn, Peter H; Finlay, Jarod C; Gallagher-Colombo, Shannon M et al. (2018) Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy. Photodiagnosis Photodyn Ther 21:28-35
Davis 4th, Richard W; Snyder, Emma; Miller, Joann et al. (2018) Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy. Photochem Photobiol :
Cramer, Gwendolyn; Simone 2nd, Charles B; Busch, Theresa M et al. (2018) Adjuvant, neoadjuvant, and definitive radiation therapy for malignant pleural mesothelioma. J Thorac Dis 10:S2565-S2573
Ong, Yi Hong; Padawer-Curry, Jonah; Finlay, Jarod C et al. (2018) Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy. Proc SPIE Int Soc Opt Eng 10476:
Ong, Yi Hong; Kim, Michele M; Huang, Zheng et al. (2018) Reactive Oxygen Species Explicit Dosimetry (ROSED) of a Type 1 Photosensitizer. Proc SPIE Int Soc Opt Eng 10476:
Zhu, Timothy C; Kim, Michele M; Padawer, Jonah et al. (2018) Light Fluence Dosimetry in Lung-simulating Cavities. Proc SPIE Int Soc Opt Eng 10476:
Chandra, Abhishek; Wang, Luqiang; Young, Tiffany et al. (2018) Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis. FASEB J 32:52-62
Ong, Yi Hong; Finlay, Jarod C; Zhu, Timothy C (2018) Monte Carlo modelling of fluorescence in semi-infinite turbid media. Proc SPIE Int Soc Opt Eng 10492:
Yan, Lesan; Amirshaghaghi, Ahmad; Huang, Dennis et al. (2018) Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy. Adv Funct Mater 28:
Dimofte, Andreea; Finlay, Jarod; Ong, Yi Hong et al. (2018) A quality assurance program for clinical PDT. Proc SPIE Int Soc Opt Eng 10476:

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