The Administrative Core (ADM) of the Program Project in Structural Cell Biology of DNA Repair Machines (SBDR) will coordinate all administrative aspects of the Program and facilitate interaction among the Investigators. Our goal is to maintain the SBDR program coherence, focus, and progress to ensure the successful conduct of the proposed research. Specifically, the ADM Core will provide administrative infrastructure, ensure milestones are met, and promote interaction and efficient communication among SBDR Projects and Cores and with the wider DNA repair and cancer research communities. The infrastructure for the Administrative Core is already in place and operating efficiently, having been established during the nine-year history of SBDR. ADM Core goals will be accomplished through three specific aims:
Aim 1. Provide management support to the SBDR Program.
Aim 2. Facilitate and monitor SBDR progress and effective allocation of shared research Core efforts.
Aim 3. Ensure effective communication between the NCI, investigators, and postdoctoral fellows. Management of the SBDR Program will be provided by an administrative structure that formally consists of Drs. Priscilla Cooper and John Tainer as Core Director and Deputy Director, respectively, together with the Program Communications Coordinator and an Executive Committee comprised of the Project Leaders, selected additional Sr. Investigators, and the EMB and SCB Core Directors. An External Advisory Board comprised of leading investigators in DNA repair, structural biology, and cancer biology will annually review the progress of the Program and make recommendations to the ADM Core Director and Deputy Director. The successful operation of the SBDR Program for 21 investigators at 15 institutions depends heavily on excellent communications and program management capabilities. The Administrative Core serves to provide a central point of contact for all operational matters with in SBDR. This includes providing budget management support, coordinating preparation of annual progress reports, monitoring progress toward overall SBDR goals, maintaining effective and equitable access to the shared resource Cores, and organizing regular teleconferences and web-based conferencing, postdoc webinars, and annual workshops for all investigators and SBDR fellows.
The overall goal of the SBDR Program is to develop detailed structural and mechanistic understanding of DNA Repair machines to enable identification of specific ways to control biological outcomes of cellular responses to DNA damage for cancer interventions. This effort involves experimental cycles between structural and functional studies in six Projects with 21 investigators. The ADM Core enables this multi-institutional effort by providing overall management of SBDR, facilitating communications, and fostering Program integration.
|Polyzos, Aris A; Wood, Nigel I; Williams, Paul et al. (2018) XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent. PLoS One 13:e0194580|
|Schneidman-Duhovny, Dina; Hammel, Michal (2018) Modeling Structure and Dynamics of Protein Complexes with SAXS Profiles. Methods Mol Biol 1764:449-473|
|Sung, Patrick (2018) Introduction to the Thematic Minireview Series: DNA double-strand break repair and pathway choice. J Biol Chem 293:10500-10501|
|Shen, Jianfeng; Ju, Zhenlin; Zhao, Wei et al. (2018) ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nat Med 24:556-562|
|Sengupta, Shiladitya; Yang, Chunying; Hegde, Muralidhar L et al. (2018) Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress. DNA Repair (Amst) 66-67:1-10|
|Mu, Hong; Geacintov, Nicholas E; Broyde, Suse et al. (2018) Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair. DNA Repair (Amst) :|
|Chavez, Diana A; Greer, Briana H; Eichman, Brandt F (2018) The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression. J Biol Chem 293:8484-8494|
|Wang, Jing L; Duboc, Camille; Wu, Qian et al. (2018) Dissection of DNA double-strand-break repair using novel single-molecule forceps. Nat Struct Mol Biol 25:482-487|
|Crickard, J Brooks; Kaniecki, Kyle; Kwon, Youngho et al. (2018) Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase. Proc Natl Acad Sci U S A 115:E10041-E10048|
|Syed, Aleem; Tainer, John A (2018) The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair. Annu Rev Biochem 87:263-294|
Showing the most recent 10 out of 484 publications