The Leadership Core is a resource comprised of the individuals who will provide twoessential components of the P01. The first is the central organizational, operational, andoversight coordination. The second is the planning, preparation, coordination, andperformance of the statistical analyses, including the interpretation of molecularmicroarrays. The Leadership Core includes the Program Director, the Co-ProgramDirector, the Coordinators of Molecular Array Technology and Inter-Project Integration,the Biostatistician, and Liaisons to the Departments of Medicine and Pathology.A major purpose of this core is to promote the integration of the five projects andthe Imaging Core. It must be emphasized that the projects are being conducted inwell-established, highly-productive laboratories that are led by some of theleaders in the field of cancer research and basic biological science. Hence, theprime form of cooperation/collaboration among the projects consists of theexchange of concepts, bio-constructs including transgenic mice, uniquechemicals, imaging expertise, methods for the characterization of genotypes andphenotypes, and constructive deliberation concerning the design, conduct, andanalysis of mouse studies. In an institution the size and breadth of MSKCC itcannot be assumed that interactions happen spontaneously, so it takes concertedeffort such as the P01 to make them happen. We have enjoyed considerablebenefit in this regard from our monthly meetings and through the efforts of ourbio-statistician (Dr. Olshen), but we intend to take the process a step further bythe appointment of Dr. Mary Ellen Moynahan an accomplished scientist (Project4) and clinician as Coordinator of Inter-Project Integration. Her specific activitiesare listed in the budget justification for this core and her qualifications aredescribed below.
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