Malignant gliomas are the most common and deadly central nervous system tumor. One aspect of the Transgenic Biobank Core is to assist in production of glioma model systems in the mouse. Core A will isolate neural and tumor stem cell cultures derived from human and mouse brain tissue samples. Specifically, this core has been established to assist PPG member labs in design, production and characterization of transgenic and knockout/knock-in mouse strains and to establish, maintain and manipulate neural stem cell cultures. The core will be responsible for all aspects of mouse engineering and will provide advice on issues relating to mouse genetics, biology and cancer modeling. The Transgenic Biobank Core will establish a repository of human glioma tumor samples, establish and cryopreserve human tumor spheres for further manipulation and analysis. Furthermore, Core A will establish mouse neurospheres and tumor spheres. The core will assist in the manipulation of these cultures for purposes of gene function evaluation. Core A has two specific aims: 1). To engineer and characterize genetically engineered mouse models. 2). To establish and maintain a biorepository of glioma-relevant mouse and human tissues and cells. The Transgenic Biobank Core brings the specialized expertise, personnel and infrastructure well suited to achieve these aims.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dana-Farber Cancer Institute
United States
Zip Code
Reardon, Colin; Murray, Kaitlin; Lomax, Alan E (2018) Neuroimmune Communication in Health and Disease. Physiol Rev 98:2287-2316
Roncali, Emilie; Stockhoff, Mariele; Cherry, Simon R (2017) An integrated model of scintillator-reflector properties for advanced simulations of optical transport. Phys Med Biol 62:4811-4830
Nanavaty, Vishal; Sandhu, Ranjodh; Jehi, Sanaa E et al. (2017) Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybrids. Nucleic Acids Res 45:5785-5796
Leonard, Paul G; Satani, Nikunj; Maxwell, David et al. (2016) SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol 12:1053-1058
Hiu, Takeshi; Farzampour, Zoya; Paz, Jeanne T et al. (2016) Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain 139:468-80
Gilhooly, Neville S; Carrasco, Carolina; Gollnick, Benjamin et al. (2016) Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination. Nucleic Acids Res 44:2727-41
Liu, Rui; Yang, Guang; Zhou, Meng-Hua et al. (2016) Flotillin-1 downregulates K(+) current by directly coupling with Kv2.1 subunit. Protein Cell 7:455-60
Schrager-Lavelle, Amanda; Herrera, Leslie A; Maloof, Julin N (2016) Tomato phyE Is Required for Shade Avoidance in the Absence of phyB1 and phyB2. Front Plant Sci 7:1275
Hu, Baoli; Wang, Qianghu; Wang, Y Alan et al. (2016) Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell 167:1281-1295.e18
Poornima, Gopalakrishna; Shah, Shanaya; Vignesh, Venkadasubramanian et al. (2016) Arginine methylation promotes translation repression activity of eIF4G-binding protein, Scd6. Nucleic Acids Res 44:9358-9368

Showing the most recent 10 out of 146 publications