The administrative core will be ensuring the integrity and the integrafion of the program projects. The directors and staff members will be overseeing the following special tasks: 1. Program Management - The core director will set specific program aims in a timely manner to maintain program goals. He will propose strategies to overcome any shortcomings and consult with external/internal board members to resolve them to achieve integration of program goals. To ascertain the integrity of the program projects, the director will implement collaborafive research agreements among institutions involved in the program projects, and employ consultancy agreements with the external/internal advisory members. 2. Program Coordination and Communication - The administrafive core will establish effecfive communication with program members to communicate on a daily basis and access information and announcements. The core staff will coordinate meefings. Additionally, to conduct ongoing research more effecfively, the core director and program members will share scientific literature and attend national and international conferences related to their projects. A steering committee composed of the four project leaders and the primary statistician will meet quartely or whenever necessary through teleconferences to update program progress. The director and staff will distribute data, announce any significant discoveries, edit manuscripts and prepare meeting abstracts. The staff members will collect experimental data and publication lists for annual progress reports for the external/internal advisory board members and for program continuation applicafion. 3. Program Evaluation - To enhance interacfions and integration among projects, Dr. Muller will continue to join monthly workshops through teleconference, and the annual external/internal advisory review meefing will be held separately during Dr. Muller's visit. The four project leaders will submit written reports before meefings and the orally present project progress and propose future strategies during the meefings. The external/internal advisory board will summarize critiques to improve the program projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA099031-08
Application #
8381364
Study Section
Special Emphasis Panel (ZCA1-RPRB-O)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$90,571
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Yamaguchi, H; Du, Y; Nakai, K et al. (2018) EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. Oncogene 37:208-217
Joshi, Sonali; Yang, Jun; Wang, Qingfei et al. (2017) 14-3-3? loss impedes oncogene-induced mammary tumorigenesis and metastasis by attenuating oncogenic signaling. Am J Cancer Res 7:1654-1664
Mazumdar, Abhijit; Poage, Graham M; Shepherd, Jonathan et al. (2016) Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. Breast Cancer Res Treat 158:441-54
Haukaas, Tonje H; Euceda, Leslie R; Giskeødegård, Guro F et al. (2016) Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes. Cancer Metab 4:12
Lim, Seung-Oe; Li, Chia-Wei; Xia, Weiya et al. (2016) EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape. Cancer Res 76:1284-96
Ko, How-Wen; Lee, Heng-Huan; Huo, Longfei et al. (2016) GSK3? inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget 7:57131-57144
Wang, Yan; Hsu, Jung-Mao; Kang, Ya'an et al. (2016) Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. Cancer Res 76:7049-7058
Du, Yi; Yamaguchi, Hirohito; Wei, Yongkun et al. (2016) Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med 22:194-201
Li, Chia-Wei; Xia, Weiya; Lim, Seung-Oe et al. (2016) AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res 76:1451-62
Mitra, Shreya; Federico, Lorenzo; Zhao, Wei et al. (2016) Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget 7:40252-40265

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