Core C is the animal core. The core will provide technical service to preclinical projects 1, and 2 establishingsubcutaneous and systemic tumor models, assessing uptake of radiolabeled agents, determining therapeuticefficacy of radiolabeled antibody conjugates and haptens, and identifying toxicity associated with single and multimodaltreatment protocols. It will also collect blood for toxicity assessments and tissue for the histological analysis.by Core E. It will use 2 F/T technicians to manage 2160-2560 mice per year in its AAALAC-accredited facility.Specifically it will be responsible for the following tasks: (a) developing new tumor models in untreated andimmunosuppressed mice, (b) injecting cultured tumor cells intravenously or subcutaneously in SCID mice or nudemice, (c) dosing animals with appropriate therapeutic agents [e.g., bispecific antibodies, radiolabeled haptens,radioantibodies, naked antibodies, and chemotherapeutics], (d) monitoring survival, body weight changes and onsetof hind-leg paralysis in systemic tumor models and measuring tumor size of subcutaneous tumors by 3D calipermeasurements, (e) performing biodistribution studies, (f) providing fixed samples of tumors and tissues for histologyto monitor viability and to monitor expression of antigens by immunohistology and for microautoradiography studies,(g) collecting blood samples for white blood cell and platelet enumeration and for measurement of cardiac troponin inproject 4, (h) entering all data (biodistribution, therapy, WBC/Plt, body weight) into Excel spreadsheets, and (i)setting up immunoscintigraphy studies.
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