The Dosimetry Core has been established at CMMI for about 6 years. The purpose of this core was todevelop standard procedures for processing pharmacokinetic and dosimetry data for CMMI-sponsoredclinical trials, but this core also assists investigators at CMMI in preclinical evaluation. The core isresponsible for first training sites in the methodology that CMMI requires of its imaging protocols andensures all equipment, both internally and at extramural sites, are properly calibrated and maintained. Thecore receives digital and hard copies of all imaging studies performed by investigational sites for CMMIclinical protocols. The core will then reviews these images and prepares regions of interest from whichtime-activity curves can be generated. A trained nuclear physician and a nuclear medicine technologistsupervise this work. As an additional quality assurance check, CMMI also has these data reviewed by aqualified radiation health physicist (for this Program Project, Dr. Jeff Siegel). This core also isresponsible for processing pharmacokinetic data.
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