Abstract

The Core Component will provide efficient, high quality support on cytometry, quantitative biology and proteomics to the Program Project. The Core will oversee the operation and/or maintenance of flow cytometry, image analysis and gel densitometry facilities, as well as the """"""""Precision Thermal and Gas Environment Suite"""""""". Core B will also function as a connecting point for the Program Project with the Protein Chemistry Laboratory of Washington University for protein identification. The Core will also collaborate with Project researchers in developing and adopting research applications in these areas covered by the Core for their study. By consolidating these functions into the Core, we expect efficient, cost effective use of the Core resources that will benefit each Project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA104457-04
Application #
7475636
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
4
Fiscal Year
2007
Total Cost
$141,600
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Wang, Rongsheng E; Pandita, Raj K; Cai, Jianfeng et al. (2012) Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode. Chembiochem 13:97-104
Wang, Rongsheng E; Hunt, Clayton R; Chen, Jiawei et al. (2011) Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins. Bioorg Med Chem 19:4710-20
Thirupathi Reddy, Y; Narsimha Reddy, P; Koduru, Srinivas et al. (2010) Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones. Bioorg Med Chem 18:3570-4
Reddy, Y Thirupathi; Sekhar, Konjeti R; Sasi, Nidhish et al. (2010) Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents. Bioorg Med Chem Lett 20:600-2
Pruitt, Rory; Sasi, Nidhish; Freeman, Michael L et al. (2010) Radiosensitization of cancer cells by hydroxychalcones. Bioorg Med Chem Lett 20:5997-6000
Penthala, Narsimha Reddy; Yerramreddy, Thirupathi Reddy; Crooks, Peter A (2010) Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines. Bioorg Med Chem Lett 20:591-3
Geng, Ling; Rachakonda, Girish; Morré, D James et al. (2009) Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature. FASEB J 23:2986-95
Zeng, Sicong; Xiang, Tao; Pandita, Tej K et al. (2009) Telomere recombination requires the MUS81 endonuclease. Nat Cell Biol 11:616-23
Wang, Rongsheng E; Kao, Jeffrey L-F; Hilliard, Carolyn A et al. (2009) Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives. J Med Chem 52:1912-21
Vanderwaal, Robert P; Maggi Jr, Leonard B; Weber, Jason D et al. (2009) Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization. Cancer Res 69:6454-62

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