Abstract

The Biostatistics and Bioinformatics Core provides assistance in the research efforts of investigators associated with this Program Project. Collaboration with clinical and laboratory investigators involves contributions to the design and analysis of the proposed studies. The biostatisticians will identify lists of differentially expressed genes using appropriate statistical criteria. They will also identify interesting gene expression patterns using both unsupervised and supervised techniques. Subsequent Bioinformatics analysis, using pathway information, will be used to prioritize target selection from the large differentially expressed gene lists and to help understand the biological meaning of the expression patterns. If the current statistical or bioinformatics methodology does not adequately address a proposal, alternative methodologies will be explored.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA106450-03
Application #
7556977
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
3
Fiscal Year
2007
Total Cost
$435,390
Indirect Cost

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Kushner, Brian H; Ostrovnaya, Irina; Cheung, Irene Y et al. (2016) Lack of survival advantage with autologous stem-cell transplantation in high-risk neuroblastoma consolidated by anti-GD2 immunotherapy and isotretinoin. Oncotarget 7:4155-66
Cheung, Nai-Kong V; Cheung, Irene Y; Kramer, Kim et al. (2014) Key role for myeloid cells: phase II results of anti-G(D2) antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma. Int J Cancer 135:2199-205
Dobrenkov, Konstantin; Cheung, Nai-Kong V (2014) GD2-targeted immunotherapy and radioimmunotherapy. Semin Oncol 41:589-612
Kushner, Brian H; Modak, Shakeel; Kramer, Kim et al. (2014) Striking dichotomy in outcome of MYCN-amplified neuroblastoma in the contemporary era. Cancer 120:2050-9
O'Neill, Alison; Shah, Nilay; Zitomersky, Naamah et al. (2013) Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature. Sarcoma 2013:450478
Kushner, Brian H; Modak, Shakeel; Basu, Ellen M et al. (2013) Posterior reversible encephalopathy syndrome in neuroblastoma patients receiving anti-GD2 3F8 monoclonal antibody. Cancer 119:2789-95
Ahn, Eun Hyun; Mercado, Gabriela E; Laé, Marick et al. (2013) Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma. Oncol Rep 30:968-78
Lessnick, Stephen L; Ladanyi, Marc (2012) Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets. Annu Rev Pathol 7:145-59
Cheung, Irene Y; Hsu, Katharine; Cheung, Nai-Kong V (2012) Activation of peripheral-blood granulocytes is strongly correlated with patient outcome after immunotherapy with anti-GD2 monoclonal antibody and granulocyte-macrophage colony-stimulating factor. J Clin Oncol 30:426-32
Shukla, Neerav; Ameur, Nabahet; Yilmaz, Ismail et al. (2012) Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways. Clin Cancer Res 18:748-57

Showing the most recent 10 out of 47 publications