Unlike other ethnic groups who attribute their origin to a single country, Hmong Americans originate from? the mountainous regions at the confluence of Vietnam, Cambodia, and Laos. The U.S. government resettled? Hmong who escaped from Southeast Asia to California and the Midwest. At the time of migration, the? Hmong were pre-literate, believed in animism, and were accustomed to an agrarian lifestyle. Our latest? California data indicate that the age-adjusted male incidence rate for liver cancer for Hmong is 25.7/100,000? compared to 3.7/100,000 for non-Hispanic white males and 8.8/100,000 for female Hmong compared to? 1.5/100,000 in non-Hispanic White females.? The purpose of this study is to increase the hepatitis B serological testing for Hmong adults and? secondarily to increase their knowledge levels of hepatitis B and liver cancer. Over the five year research? tudy, we propose to: (1) measure the baseline proportion seroloically tested for hepatitis B [HBV] among? Hmong, ages 18-64, in the Greater Sacramento Area; (2) Develop an intervention using lay health workers? to promote serological testing for HBV and increase knowledge of HBV among Hmong adults; (3) Evaluate? the effectiveness of the lay health worker intervention by conducting a randomized, controlled trial among? Hmong adults aged 18-64 not previously tested for HBV; and (4) Characterize facilitating and impeding? factors associated with serological testing for HBV among Hmong adults. To achieve these Aims, universitybased? researchers will work collaboratively with Hmong bilingual interviewers, community leaders, and? agencies in conducting a baseline assessment of serological testing among Hmong and follow with? randomizing those who have not been serologically tested for HBV into intervention or control conditions.? We shall use the Health Behavior Framework to guide our study and the lay health worker teams as the? intervention agents . Intervention effectiveness will be based on the basis of self-reported serological testing? rates that will be also verified through medical records check. We have detailed the training and evaluation? of lay health workers and have incorporated rigorous safeguards to minimize contamination. As a? consequence of this study, we expect data on the empirical effectiveness of a lay health worker intervention? model for increasing serological testing for HBV and that the burden of HBV-induced liver cancer reduced.

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National Cancer Institute (NCI)
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Subcommittee G - Education (NCI)
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University of California Davis
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Tepper, Clifford G; Dang, Julie H T; Stewart, Susan L et al. (2018) High frequency of the PNPLA3 rs738409 [G] single-nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease. Cancer 124 Suppl 7:1583-1589
Chen Jr, Moon S; Chow, Edward A; Nguyen, Tung T (2018) The Asian American Network for Cancer Awareness, Research, and Training (AANCART)'s contributions toward reducing Asian American cancer health disparities, 2000-2017. Cancer 124 Suppl 7:1527-1534
Fang, Dao M; Stewart, Susan L (2018) Social-cultural, traditional beliefs, and health system barriers of hepatitis B screening among Hmong Americans: A case study. Cancer 124 Suppl 7:1576-1582
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