Core C. Cell Culture and Animal Models CoreCore C, the Cell Culture and Animal Models Core, is an integrated, dedicated, essential component of theProgram, which will provide materials and services to all four Projects of the Program. This Core supportsthe Projects by providing specialized cell culture facilities, resources and expertise, by maintaining active andfrozen stocks of cell lines used by the Projects, by providing training in cell culture techniques when neededby researchersin the Projects, and by assisting with cell culture experiments or performing cell cultureexperiments when desired by the Program Leaders. In addition, the Core will oversee an SPF animal facilityin which studies with mice can be performed. This colony is suitable for long term studies of geneticallyaltered mice, immune deficient (nude) mice and mice immunosuppressed by irradiation and/or drugtreatments. The equipment, supplies, and expertise needed to monitor animals for tumor development and toimplant, measure,and treat tumors will be available in this Core facility. When desired by the ProjectLeaders, the Core will maintain mouse strains and animal tumor model systems, will train Project staff in thetechniques used with these model systems, and will participate in the design, performance, and analysisofexperiments using these mouse model systems.
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