The purpose of Program Integration and Management is to ensure the successful outcome of the Program by maintaining its focus and coherence, and continually monitoring its progress. Management of the Program will be carried out by the PD/PI and three project leaders with the assistance of Program staff at the three Program sites.
Specific Aim 1 is to monitor, coordinate, and integrate the progress of the Projects and the functionality of the Cores. This will be accomplished by monthly videoconferences between the three sites involving the Project and Core Leaders, a semi- annual meeting alternating between campuses which will involve all Project personnel, and a yearly meeting to include Project and Core Leaders, Program staff, and an advisory panel.
Specific Aim 2 is to foster a system for exchange of scientific information, exchange of reagents, and tasking of functions between the Projects. This will be primarily accomplished by the communications in Aim 1, as well as an SharePoint web site to enable monitoring and prioritizing the tasks of the Research Projects assigned to the Research Cores.
Specific Aim 3 is to monitor the finances of the Program and assure compliance with NIH and Institutional regulations.
Specific Aim 4 is to coordinate the preparation of an annual progress report, and Specific Aim 5 is to coordinate an annual meeting including an advisory panel for scientific guidance of the Program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA193124-04
Application #
9849256
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2020-02-01
Budget End
2021-01-31
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Lange, Sabine S; Bhetawal, Sarita; Reh, Shelley et al. (2018) DNA polymerase ? deficiency causes impaired wound healing and stress-induced skin pigmentation. Life Sci Alliance 1:
Wang, Hailong; Li, Shibo; Oaks, Joshua et al. (2018) The concerted roles of FANCM and Rad52 in the protection of common fragile sites. Nat Commun 9:2791
Tomida, Junya; Takata, Kei-Ichi; Bhetawal, Sarita et al. (2018) FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells. EMBO J 37:
Knijnenburg, Theo A; Wang, Linghua; Zimmermann, Michael T et al. (2018) Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. Cell Rep 23:239-254.e6
Tian, Yanyan; Shen, Xi; Wang, Rui et al. (2017) Constitutive role of the Fanconi anemia D2 gene in the replication stress response. J Biol Chem 292:20184-20195
Klages-Mundt, Naeh L; Li, Lei (2017) Formation and repair of DNA-protein crosslink damage. Sci China Life Sci 60:1065-1076
Reh, Wade A; Nairn, Rodney S; Lowery, Megan P et al. (2017) The homologous recombination protein RAD51D protects the genome from large deletions. Nucleic Acids Res 45:1835-1847
Takata, Kei-Ichi; Reh, Shelley; Yousefzadeh, Matthew J et al. (2017) Analysis of DNA polymerase ? function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet 13:e1006818
Manandhar, Mandira; Lowery, Megan G; Boulware, Karen S et al. (2017) Transcriptional consequences of XPA disruption in human cell lines. DNA Repair (Amst) 57:76-90