The role of the Biostatistics Core in this Program is to provide biostatistical expertise in study design, data analysis, and data management. The Core is staffed by three statisticians, and is led by Elizabeth Garrett- Mayer, PhD who has substantial experience and previous success as a P01 Core leader. Biostatisticians from this Core have worked with investigators in all Projects to optimize experimental designs, to assist with study planning including sample size justification and to perform analysis of the data resulting from experiments. Analytic plans have been developed for each Project and each aim by Core biostatisticians, which include in vitro studies, in vivo animal experiments, translational studies and clinical trials. Centralization will foster bonds and communication between Project Leaders and statistical collaborators, facilitate matching of investigators with the most appropriate statistical collaborator, and contribute to dissemination of state-of-the art analysis techniques.
The Biostatistics Core will provide biostatistical support and expertise for the entire Program. This includes study design, data analysis, data management, reporting of results, and assistance with manuscript preparation.
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|Ogretmen, Besim (2018) Sphingolipid metabolism in cancer signalling and therapy. Nat Rev Cancer 18:33-50|
|Helke, Kristi; Angel, Peggi; Lu, Ping et al. (2018) Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep 8:1627|
|Chatterjee, Shilpak; Daenthanasanmak, Anusara; Chakraborty, Paramita et al. (2018) CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab 27:85-100.e8|
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|Britten, Carolyn D; Garrett-Mayer, Elizabeth; Chin, Steven H et al. (2017) A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res 23:4642-4650|
|Lv, Zongyang; Rickman, Kimberly A; Yuan, Lingmin et al. (2017) S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell 65:699-714.e6|
|Thomas, Raquela J; Oleinik, Natalia; Panneer Selvam, Shanmugam et al. (2017) HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. EMBO Mol Med 9:1030-1051|
|Scheffel, Matthew J; Helke, Kristi; Lu, Ping et al. (2017) Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Sci Rep 7:15552|
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