The proposed project aims to address a current gap in our understanding of the role of biological sex in overall survival among melanoma AJCC TNM stages IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID. We will evaluate methylome alterations and mutational burden in the primary tumors of 1000 melanoma patients with the goal of 1) identifying underlying mechanisms for observed disparities in melanoma overall survival between men and women, and 2) identifying subclasses of methylome alterations and mutational signatures associated with sex and survival.
/PUBLIC HEALTH RELEVANCE The proposed project aims to address a current gap in our understanding of the role of biological sex in overall survival among melanoma AJCC TNM stages IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID. Data from the proposed project will provide insight into the link between sex, epigenetics and genetic mutational load, and melanoma survival, and will provide insight into important biomarkers for melanoma progression, and inform clinical decisions about the use of adjuvant immunotherapy. This important step towards increasing our understanding of the relationship between biological sex, methylation alterations, and tumor mutational burden, will be used to develop additional studies, setting the stage for additional breakthroughs in factors important for melanoma survival.
Thomas, Nancy E; Edmiston, Sharon N; Orlow, Irene et al. (2018) Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes. J Invest Dermatol 138:2398-2404 |
Gorlov, Ivan; Orlow, Irene; Ringelberg, Carol et al. (2018) Identification of gene expression levels in primary melanoma associated with clinically meaningful characteristics. Melanoma Res 28:380-389 |
Miles, Jonathan A; Orlow, Irene; Kanetsky, Peter A et al. (2018) Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based GEM Study. J Invest Dermatol : |
Gorlov, Ivan P; Pikielny, Claudio W; Frost, Hildreth R et al. (2018) Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples. BMC Bioinformatics 19:430 |
Thomas, Nancy E; Edmiston, Sharon N; Tsai, Yihsuan S et al. (2018) Utility of TERT Promoter Mutations for Cutaneous Primary Melanoma Diagnosis. Am J Dermatopathol : |