The real-life consequences of drug use cannot be determined with laboratory-controlled experimental studies. The complete nature and extent of these consequences may not appear until many years after adolescence into adulthood. We use a unique, rich, and comprehensive database over a 20-year span of our subjects lives with careful and complex analyses to evaluate whether drug use has a reliable impact on changing physical and psychosocial functioning later in life. This project uses a unique and rich 20-year database to conduct comprehensive structural equation model analyses of these data. We develop contrast, elaborate, and refine current theories to explain and predict the long-term psychosocial and health-related consequences of using drugs as a teenager or young adult, and evaluate these theories using latent-variable models. In addition, a few carefully selected multi-wave prospective data bases will also be analyzed in cooperation with their owners to cross- validate and extend our findings.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Program Projects (P01)
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University of California Los Angeles
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Hunt, Tyler D; Bentler, Peter M (2015) Quantile lower bounds to reliability based on locally optimal splits. Psychometrika 80:182-95
Upchurch, Dawn M; Stein, Judith; Greendale, Gail A et al. (2015) A Longitudinal Investigation of Race, Socioeconomic Status, and Psychosocial Mediators of Allostatic Load in Midlife Women: Findings From the Study of Women's Health Across the Nation. Psychosom Med 77:402-12
Campos, Belinda; Ullman, Jodie B; Aguilera, Adrian et al. (2014) Familism and psychological health: the intervening role of closeness and social support. Cultur Divers Ethnic Minor Psychol 20:191-201
Attonito, Jennifer; Dévieux, Jessy G; Lerner, Brenda D G et al. (2014) Antiretroviral treatment adherence as a mediating factor between psychosocial variables and HIV viral load. J Assoc Nurses AIDS Care 25:626-37
Rotheram-Borus, Mary Jane; Stein, Judith A; Rice, Eric (2014) Intervening on conflict, parental bonds, and sexual risk acts among adolescent children of mothers living with HIV. PLoS One 9:e101874
Chin, Dorothy; Myers, Hector F; Zhang, Muyu et al. (2014) Who Improved in a Trauma Intervention for HIV-Positive Women with Child Sexual Abuse Histories? Psychol Trauma 6:152-158
Bentler, Peter M; Huang, Wenjing (2014) On Components, Latent Variables, PLS and Simple Methods: Reactions to Rigdon's Rethinking of PLS. Long Range Plann 47:138-145
Ibabe, Izaskun; Stein, Judith A; Nyamathi, Adeline et al. (2014) Predictors of substance abuse treatment participation among homeless adults. J Subst Abuse Treat 46:374-81
Moskowitz, Amanda; Stein, Judith A; Lightfoot, Marguerita (2013) The mediating roles of stress and maladaptive behaviors on self-harm and suicide attempts among runaway and homeless youth. J Youth Adolesc 42:1015-27
Brumsey, Ayesha Delany; Joseph, Nataria T; Myers, Hector F et al. (2013) Modeling the Relationship between Trauma and Psychological Distress among HIV-Positive and HIV-Negative Women. Psychol Trauma 5:69-76

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