The overall goal of this Core Facility is to perform preclinical toxicological studies on two potent delta opioid receptor antagonists c[D-Pen2,D-Pen5]enkephalin (DPDPE) and biphalin, to prepare sterile pyrogen free injectable DPDPE and biphalin solution for preclinical toxicological studies at The University of Arizona and by Dr. Yaksh at the University of San Diego. Specifically, we will perform intravenous acute toxicology studies for DPDPE and biphalin in rats and dogs giving daily i.v. injections of either agent or 30 and 5 days, respectively. At the end of dosing the animals will be euthanized and organs will be collected, weighed and tissue slices prepared for blinded histopathological studies. If not toxic, the data from these studies will be combined with the I.T. toxicological studies of Dr. Yaksh and incorporated into an investigator-sponsored investigational New Drug Application (INDA) for each agent.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA006284-10
Application #
6104014
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
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Ramos-Colon, Cyf N; Lee, Yeon Sun; Remesic, Michael et al. (2016) Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the ? Opioid Receptor. J Med Chem 59:10291-10298
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