RESEARCH SUPPORT SUMMARY The sharing of strengths encouraged by the NIDA Program Project funding mechanism provides for greater opportunities and capabilities through the unification of a shared commitment to a central hypothetical question than would exist for any of the scientists involved individually. The main goal of the Administrative Core of this Proposal is to facilitate and support the unification and interaction of the scientists and administrative personnel working on the three Projects and two Cores of the Program Project Grant at The Rockefeller University and Yale University on this Proposal. The Administrative Core (AC) team have successfully supported the work of the researchers on this Program Project Grant for the last 14 years. Their combined expertise along with the flexibility to adapt to the changing needs of the researchers has led to the development of a proven set of methods for carrying out Specific Aims to aid the studies proposed. Through Aim I. the AC staff will facilitate coordination and communication between the Cores and Projects in the Proposal and data sharing. The AC staff will also oversee maintenance of the physical working space, supplies and equipment for the Cores and Projects 1 and 2 (Aim 11). The staff will also maintain the data and reports of the progress generated under this proposal and provide clerical support (Aim III). The AC staff will continue to utilize their expertise to integrate the various components and individuals of this Program Project Grant to ensure achievement of the goals of this application.
Administrative Core staff will utilize their combined organizational and administrative expertise to support the integration of the researchers and institutions involved in this Program Project Grant Proposal. They will facilitate the communication, maintenance and reporting requirements of the Proposal allowing the investigators to focus on the research.
|Li, Daniel; Musante, Veronica; Zhou, Wenliang et al. (2018) Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons. J Biol Chem 293:11179-11194|
|Seo, J-S; Zhong, P; Liu, A et al. (2018) Elevation of p11 in lateral habenula mediates depression-like behavior. Mol Psychiatry 23:1113-1119|
|Madero-Pérez, Jesús; Fdez, Elena; Fernández, Belén et al. (2018) Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation. Mol Neurodegener 13:3|
|Chang, Audrey N; Gao, Ning; Liu, Zhenan et al. (2018) The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1c?, is essential for smooth muscle contraction. J Biol Chem 293:16677-16686|
|Nishi, Akinori; Matamales, Miriam; Musante, Veronica et al. (2017) Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution. J Biol Chem 292:1462-1476|
|Andrade, Erika C; Musante, Veronica; Horiuchi, Atsuko et al. (2017) ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). J Neurosci 37:2709-2722|
|Musante, Veronica; Li, Lu; Kanyo, Jean et al. (2017) Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. Elife 6:|
|Milosevic, Ana; Liebmann, Thomas; Knudsen, Margarete et al. (2017) Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain. J Comp Neurol 525:955-975|
|Ceglia, Ilaria; Lee, Ko-Woon; Cahill, Michael E et al. (2017) WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. Proc Natl Acad Sci U S A 114:1395-1400|
|Seo, J-S; Wei, J; Qin, L et al. (2017) Cellular and molecular basis for stress-induced depression. Mol Psychiatry 22:1440-1447|
Showing the most recent 10 out of 205 publications